{"id":"W2025378764","doi":"10.1002/ddr.10301","title":"Proteinase‐activated receptors: Tethered ligands and receptor‐activating peptides","year":2003,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Servier; Kidney Foundation of Canada","keywords":"Receptor; Proteolysis; G protein-coupled receptor; Protease-activated receptor; Biochemistry; Ligand (biochemistry); Cell biology; Chemistry; Enzyme-linked receptor; Peptide sequence; Signal transduction; 5-HT5A receptor; Extracellular; Biology; Functional selectivity; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002525655,0.0002022995,0.0003033215,0.0003644523,0.0004838184,0.00008597603,0.00009512276,0.000126512,0.0007833489],"category_scores_gemma":[0.0008602763,0.0001733352,0.00003556173,0.0007793054,0.0001100991,0.0001407219,0.00008638699,0.0005702183,0.0001617655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007397,"about_ca_system_score_gemma":0.0005400886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002380414,"about_ca_topic_score_gemma":0.00000606614,"domain_scores_codex":[0.9974434,0.0002571764,0.0003491877,0.0004807811,0.0008949215,0.0005745159],"domain_scores_gemma":[0.9987338,0.0002063858,0.00006808905,0.0002738991,0.0004162877,0.0003015674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001913157,0.0005219353,0.01549682,0.0002774332,0.0002150601,0.00001684197,0.005467888,7.231272e-7,0.9226488,0.004458192,0.005021666,0.04568335],"study_design_scores_gemma":[0.001206434,0.00009902428,0.004185926,0.0003326857,0.000005125885,0.00001181719,0.002281074,0.00001030827,0.9182286,0.0003540165,0.07308614,0.0001988442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863346,0.0001597855,0.00006444482,0.001107144,0.0001001951,0.001023144,6.31308e-7,0.0001193561,0.01109075],"genre_scores_gemma":[0.9735791,0.0000698174,0.015945,0.00009214078,0.00005394395,0.0001839852,0.00002701495,0.00004590262,0.0100031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06806447,"threshold_uncertainty_score":0.8577121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07557279785949038,"score_gpt":0.3492024730517636,"score_spread":0.2736296751922732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}