{"id":"W2025405517","doi":"10.1016/j.bbagrm.2009.01.007","title":"Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells","year":2009,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Hong Kong University of Science and Technology; National Institutes of Health; University of Calgary","keywords":"Biology; Promoter; Chromatin immunoprecipitation; Transcription factor; CREB; Transcription (linguistics); Molecular biology; Transcriptional regulation; Response element; Electrophoretic mobility shift assay; Cell biology; Gene expression; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904841,0.0002538384,0.0002206184,0.000475176,0.0004589298,0.0006132752,0.0002613355,0.0003319274,0.001651818],"category_scores_gemma":[0.0002649604,0.0002455457,0.0003791324,0.0002381152,0.0003792045,0.000435642,0.0004592196,0.0006546448,0.0005663335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009157403,"about_ca_system_score_gemma":0.0005052593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002497424,"about_ca_topic_score_gemma":0.003944459,"domain_scores_codex":[0.9998097,0.00002812792,0.0000104659,0.00003052345,0.00004797738,0.00007312816],"domain_scores_gemma":[0.9998428,0.00003357432,0.00001928566,0.00001392166,0.00003481949,0.00005564484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004060838,0.0000313595,0.0009132622,0.00002632729,0.000007176916,0.0001217671,0.00007821382,0.00006670411,0.9954329,0.0007445833,0.0001320787,0.002039724],"study_design_scores_gemma":[0.0000726294,0.0002019302,0.03270114,0.00001647939,0.00002398629,0.000611691,0.0004190487,0.002518838,0.9578584,0.001282334,0.004281559,0.00001191582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901125,0.002805342,0.003019113,0.0002051388,0.00004893667,0.00001618212,0.0003625308,0.00006401388,0.003366197],"genre_scores_gemma":[0.9936744,0.0008108405,0.001431455,0.0000688025,0.00001951255,0.00002472559,0.0006136357,0.00003370922,0.003322959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002497424,"threshold_uncertainty_score":0.006644189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069510984336514,"score_gpt":0.2220611305460259,"score_spread":0.2113660207026607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}