{"id":"W2025410059","doi":"10.1016/j.jsb.2010.06.008","title":"High-throughput production of human proteins for crystallization: The SGC experience","year":2010,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Innovation Trust; Wellcome Trust; Novartis Foundation; GlaxoSmithKline","keywords":"Crystallization; Throughput; Production (economics); Chemistry; Computational biology; Cell biology; Computer science; Biology; Organic chemistry; Operating system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005294313,0.0009941842,0.001539957,0.000867563,0.0005940582,0.002074162,0.001493939,0.001253032,0.001985407],"category_scores_gemma":[0.00270837,0.0004741103,0.0008631101,0.001589695,0.000729722,0.0009310982,0.001155788,0.002506833,0.002723944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001653583,"about_ca_system_score_gemma":0.001621667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003352894,"about_ca_topic_score_gemma":0.002607263,"domain_scores_codex":[0.9982769,0.0003838468,0.00009599089,0.0003139368,0.0008354022,0.00009383112],"domain_scores_gemma":[0.9984164,0.0003061164,0.00008230232,0.0003635663,0.0004862167,0.0003454703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001132447,0.0006384424,0.002573944,0.001390345,0.0002834518,0.0006156948,0.0008764889,0.005000768,0.8016999,0.007393377,0.05423263,0.1241626],"study_design_scores_gemma":[0.0002402834,0.0008933335,0.005607727,0.000140975,0.0002435626,0.0022249,0.0001382206,0.01132454,0.7197019,0.003081553,0.2563124,0.0000904901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3818519,0.0475812,0.5092884,0.01453697,0.001349706,0.001368644,0.01330265,0.007935656,0.02278491],"genre_scores_gemma":[0.2663209,0.05200352,0.6177178,0.001522582,0.0005782993,0.0006878752,0.04302818,0.002370615,0.01577018],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005294313,"threshold_uncertainty_score":0.02799934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588304003086491,"score_gpt":0.2907066975139569,"score_spread":0.2748236574830921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}