{"id":"W2025423007","doi":"10.1111/j.1574-6968.2009.01802.x","title":"Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027","year":2009,"lang":"en","type":"article","venue":"FEMS Microbiology Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Chinese Academy of Medical Sciences","keywords":"Flavin group; Hydroxylation; Enediyne; Biosynthesis; Flavin adenine dinucleotide; Stereochemistry; Reductase; Chemistry; Enzyme; Flavoprotein; Monooxygenase; Biochemistry; Oxidoreductase; Cofactor; Cytochrome P450","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992889,0.0001868636,0.000241222,0.0001779227,0.00007558283,0.0002412434,0.0001170458,0.0001588593,0.0003883338],"category_scores_gemma":[0.0002763467,0.00008333489,0.0001409575,0.0001757412,0.0001010317,0.0001524681,0.00009379275,0.000227695,0.000352731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002242239,"about_ca_system_score_gemma":0.0001782943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143409,"about_ca_topic_score_gemma":0.001166062,"domain_scores_codex":[0.9999248,0.0000164644,0.000005283147,0.00001739659,0.0000231812,0.00001302399],"domain_scores_gemma":[0.9998533,0.00003580288,0.00001818164,0.00001938507,0.00004329258,0.00003008449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001128673,0.00002592935,0.0009840206,0.0000190129,0.000004514904,0.00002704425,0.00001975121,0.0001843824,0.9963653,0.00006778006,0.0000256975,0.002163778],"study_design_scores_gemma":[0.000009015716,0.0001726892,0.01351974,0.000004717448,0.00001015832,0.0001837573,0.0000586977,0.004019558,0.9803252,0.00005620188,0.001632712,0.000007622872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957028,0.000832713,0.002173781,0.00006050217,0.00001049358,0.0000126343,0.000588503,0.0000332613,0.0005852722],"genre_scores_gemma":[0.9940704,0.0002827675,0.00287619,0.0000167899,0.000003902314,0.000005327462,0.001572318,0.00001432235,0.001158012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143409,"threshold_uncertainty_score":0.002851486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008181439304515151,"score_gpt":0.2220191862157656,"score_spread":0.2138377469112504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}