{"id":"W2025424557","doi":"10.1139/y10-085","title":"Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Apoptosis; Annexin; Cell growth; Molecular biology; Cell biology; Cell cycle; Biology; Programmed cell death; Fragmentation (computing); Cancer cell; Fas receptor; Flow cytometry; Cell; MTT assay; Chemistry; Biochemistry; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007888263,0.0003113874,0.0003195324,0.000281522,0.000159138,0.0001572958,0.00008283045,0.0001525354,0.00119525],"category_scores_gemma":[0.00008515838,0.0000849309,0.0002882575,0.0002166101,0.0001006684,0.0001258591,0.0001457332,0.0003410708,0.0003958219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000226705,"about_ca_system_score_gemma":0.0002335895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002088547,"about_ca_topic_score_gemma":0.003519871,"domain_scores_codex":[0.9999154,0.00001741231,0.000009749519,0.00001037297,0.00002352669,0.00002359079],"domain_scores_gemma":[0.9999595,0.000007792843,0.000007309508,0.000006144308,0.00001038956,0.000008891443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005069958,0.0001518249,0.0008674833,0.0002125628,0.00002136916,0.0002427037,0.00005407178,0.0001640141,0.9906268,0.00008050312,0.0003338158,0.006737906],"study_design_scores_gemma":[0.0001596677,0.002266795,0.01700519,0.00003658069,0.00005737009,0.000905139,0.0001779005,0.0013959,0.9677721,0.0001088611,0.01010086,0.00001367644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821671,0.01021579,0.002094234,0.0002592316,0.00009481525,0.00006022779,0.0006355487,0.0001318553,0.004341073],"genre_scores_gemma":[0.9899718,0.003826878,0.0006397759,0.00009715063,0.00001764122,0.0000467247,0.001147961,0.00001407411,0.004237979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002088547,"threshold_uncertainty_score":0.004152775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06374126087315204,"score_gpt":0.3714839500300471,"score_spread":0.3077426891568951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}