{"id":"W2025452617","doi":"10.1210/mend.15.8.0679","title":"NF-1C, Sp1, and Sp3 Are Essential for Transcription of the Human Gene for P450c17 (Steroid 17α-hydroxylase/17,20 lyase) in Human Adrenal NCI-H295A Cells","year":2001,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; School of Medicine, New York University; York University","keywords":"Biology; Molecular biology; Transcription factor; Promoter; Gene; Transcription (linguistics); Binding site; TATA box; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049115,0.0002707952,0.0003322801,0.0001065218,0.000160413,0.00001544136,0.0003328325,0.00029352,0.000008336175],"category_scores_gemma":[0.00002388154,0.0002383464,0.0002777349,0.00009232219,0.0002205184,0.000005972199,0.0001260388,0.0001774569,9.39696e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002047462,"about_ca_system_score_gemma":0.00003284726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000373794,"about_ca_topic_score_gemma":0.0001195394,"domain_scores_codex":[0.9983215,0.0001292456,0.0003796622,0.0005239155,0.0001090236,0.0005366],"domain_scores_gemma":[0.9991661,0.00001607693,0.000176566,0.0004954393,0.00007054469,0.00007531846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002251254,0.000154725,0.0004719953,0.00007569476,0.0001139923,0.00005829358,0.00003917388,0.0001778843,0.9975656,0.0003937499,0.000492084,0.0002316856],"study_design_scores_gemma":[0.003356674,0.00083064,0.0006882016,0.00002859785,0.0001284349,0.0001797624,0.0000311801,0.00007946726,0.9898783,0.0005451242,0.004008246,0.0002453885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930502,0.0020368,0.003269911,0.0002851084,0.0001806361,0.0009467087,0.0000715505,0.00001421605,0.0001449403],"genre_scores_gemma":[0.9983582,0.0001261358,0.0003528294,0.0002167154,0.0001321921,0.0001386907,0.0002374834,0.00004749245,0.0003903004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007687313,"threshold_uncertainty_score":0.9719486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007001254508707364,"score_gpt":0.2451861400589293,"score_spread":0.2381848855502219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}