{"id":"W2025452617","doi":"10.1210/mend.15.8.0679","title":"NF-1C, Sp1, and Sp3 Are Essential for Transcription of the Human Gene for P450c17 (Steroid 17α-hydroxylase/17,20 lyase) in Human Adrenal NCI-H295A Cells","year":2001,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; School of Medicine, New York University; York University","keywords":"Biology; Molecular biology; Transcription factor; Promoter; Gene; Transcription (linguistics); Binding site; TATA box; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084208,0.0005830594,0.0003466604,0.0002794213,0.0004899926,0.0002896857,0.0003085216,0.0002894187,0.003608433],"category_scores_gemma":[0.0002995701,0.0002473175,0.0004279315,0.0002793219,0.0002912995,0.0001544061,0.0002906335,0.0007279842,0.001935931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006484483,"about_ca_system_score_gemma":0.0005952127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00285167,"about_ca_topic_score_gemma":0.003454494,"domain_scores_codex":[0.9996256,0.00004036064,0.00002817017,0.00008990997,0.0001592756,0.00005668842],"domain_scores_gemma":[0.9997224,0.00004068881,0.00005415444,0.00003702223,0.00005988985,0.00008582188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009056119,0.00002772797,0.0004156804,0.00005818456,0.000004975268,0.00008056408,0.0000303091,0.00002464735,0.9974054,0.0001005324,0.0002065003,0.001554869],"study_design_scores_gemma":[0.0001441801,0.0003381514,0.05406519,0.0000627823,0.00004480374,0.001868598,0.0001645758,0.002861941,0.9028727,0.0004668315,0.03709186,0.00001845572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536406,0.0105741,0.01751158,0.0005530559,0.0002804768,0.000196846,0.01004812,0.0007718991,0.006423465],"genre_scores_gemma":[0.9511837,0.002013007,0.0123507,0.0001705174,0.00005380827,0.0002203131,0.02278447,0.0001172111,0.01110627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003608433,"threshold_uncertainty_score":0.01207143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007001254508707364,"score_gpt":0.2451861400589293,"score_spread":0.2381848855502219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}