{"id":"W2025612185","doi":"10.1016/j.antiviral.2013.04.001","title":"Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors","year":2013,"lang":"en","type":"article","venue":"Antiviral Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Integrase; DNA; High-throughput screening; HIV Long Terminal Repeat; Ligand binding assay; Biology; Binding site; Small molecule; Virology; Biochemistry; Long terminal repeat; Chemistry; Molecular biology; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116008,0.00112422,0.000890027,0.0008856429,0.0005552346,0.0007244912,0.001510929,0.001793234,0.001718933],"category_scores_gemma":[0.0008976078,0.0008196762,0.0005596768,0.0004907636,0.0004719952,0.0006548595,0.0005401779,0.00205116,0.0008549356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009873671,"about_ca_system_score_gemma":0.0006217951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381613,"about_ca_topic_score_gemma":0.003626439,"domain_scores_codex":[0.9989313,0.0002542867,0.00003473064,0.0002284264,0.0004139531,0.0001372246],"domain_scores_gemma":[0.999524,0.0001796849,0.00006853522,0.00003549625,0.0001100773,0.00008220228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005854161,0.00006098691,0.00009585112,0.00003480391,0.000009019148,0.00001276753,0.00001233142,0.000133063,0.9969042,0.0001020168,0.00006909344,0.002507166],"study_design_scores_gemma":[0.00002752736,0.0002578329,0.0006447605,0.000008032661,0.00001501876,0.0001569588,0.00001213518,0.005631352,0.9916825,0.0000569277,0.001490582,0.00001630347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6270649,0.004604845,0.3558241,0.001038132,0.0001461801,0.0008253569,0.001505223,0.001433387,0.007557626],"genre_scores_gemma":[0.6830516,0.002540669,0.3011968,0.0005857334,0.00004239295,0.0007575704,0.00218735,0.0001066268,0.009531118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793234,"threshold_uncertainty_score":0.007163882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07631490118335602,"score_gpt":0.3635628796103659,"score_spread":0.2872479784270099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}