{"id":"W2025620369","doi":"10.1080/10286020.2012.762910","title":"Reversal effect of rosmarinic acid on multidrug resistance in SGC7901/Adr cell","year":2013,"lang":"en","type":"article","venue":"Journal of Asian Natural Products Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint Mary's University","funders":"Fundamental Research Funds for the Central Universities; Central University Basic Research Fund of China; Natural Science Foundation of Shaanxi Province","keywords":"Multiple drug resistance; P-glycoprotein; Intracellular; Flow cytometry; MTT assay; Rosmarinic acid; Reverse transcription polymerase chain reaction; Cell culture; Pharmacology; Chemistry; Molecular biology; Biology; Cell; Gene expression; Drug resistance; Biochemistry; Gene; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003200822,0.0002155098,0.0007166101,0.0007900617,0.00007348078,0.00002988986,0.000393554,0.0001483236,0.00008827377],"category_scores_gemma":[0.001067956,0.0001369175,0.0001906659,0.001063419,0.0001898045,0.0002936572,0.00004343024,0.002351669,0.00005428824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002330409,"about_ca_system_score_gemma":0.0003349918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003499448,"about_ca_topic_score_gemma":0.00003787717,"domain_scores_codex":[0.9962225,0.0003965075,0.0007962065,0.000343405,0.00165112,0.0005902382],"domain_scores_gemma":[0.9977665,0.0002021829,0.0002920982,0.0004454743,0.001081341,0.0002123791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007571268,0.000551285,0.002750013,0.002306528,0.00008466975,0.0007974331,0.0009620251,0.000003451446,0.9611496,0.00009978057,0.01602574,0.007698247],"study_design_scores_gemma":[0.005328298,0.002567443,0.05551451,0.001589431,0.00004348079,0.00004663063,0.0004219669,0.00001294318,0.9314694,0.0003100695,0.002501106,0.0001947647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809105,0.004254307,0.000002005765,0.008373569,0.0005300979,0.001026212,0.000002517139,0.00001004609,0.004890773],"genre_scores_gemma":[0.9887629,0.0002984355,0.001693406,0.00003198521,0.0003988594,0.000007245935,0.000005237161,0.00003370911,0.008768272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0527645,"threshold_uncertainty_score":0.9999499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599836689630961,"score_gpt":0.3162997463646359,"score_spread":0.3003013794683262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}