{"id":"W2025625216","doi":"10.1371/journal.pone.0020012","title":"Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: A Powerful Tool for Analyzing MAP Kinase Signaling in Yeast","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Göteborgs Universitet; Canadian Institutes of Health Research; European Commission","keywords":"Kinase; Yeast; Computational biology; Signal transduction; Biology; Cell biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003063196,0.0006483186,0.000369169,0.0002947379,0.0002459675,0.0003063713,0.0004950634,0.0003459133,0.0007144259],"category_scores_gemma":[0.0001602233,0.0002354454,0.000230476,0.0003199049,0.0002007211,0.0002831014,0.0001970072,0.0005021165,0.0006011637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005058636,"about_ca_system_score_gemma":0.0005541843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008051938,"about_ca_topic_score_gemma":0.001184143,"domain_scores_codex":[0.9998506,0.00001787672,0.00001725241,0.00002908532,0.00005840825,0.00002667324],"domain_scores_gemma":[0.9998977,0.00001187314,0.00002525534,0.000008960506,0.00002494264,0.00003125151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006005082,0.00004949218,0.0000462711,0.00008841853,0.000007546263,0.00003390506,0.000009883229,0.0005007419,0.9945147,0.000226209,0.00009955849,0.00436324],"study_design_scores_gemma":[0.00002955233,0.0001970977,0.0002396026,0.000004256064,0.0000131953,0.00007839251,0.000003927038,0.000555096,0.991796,0.00002839294,0.007048026,0.000006416563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7696062,0.01186392,0.202233,0.0006333041,0.0001466617,0.002059812,0.005858038,0.0009167325,0.006682144],"genre_scores_gemma":[0.8563737,0.01140288,0.1178282,0.0001845825,0.00003966617,0.00070141,0.005275217,0.0002411529,0.007953252],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0008051938,"threshold_uncertainty_score":0.003670335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02889650111097444,"score_gpt":0.232000884395113,"score_spread":0.2031043832841385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}