{"id":"W2025639562","doi":"10.1074/jbc.m113.470948","title":"Carbamazepine as a Novel Small Molecule Corrector of Trafficking-impaired ATP-sensitive Potassium Channels Identified in Congenital Hyperinsulinism","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Diazoxide; Sulfonylurea receptor; Carbamazepine; Potassium channel; Hyperinsulinism; Pinacidil; Chemistry; Pharmacology; Potassium channel opener; Kir6.2; Congenital hyperinsulinism; Cell biology; Endocrinology; Internal medicine; Biochemistry; Biology; Insulin; Medicine; Glibenclamide; Neuroscience; Epilepsy; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874854,0.0002239648,0.0008038011,0.00006242275,0.00002555993,0.00001933118,0.0001565492,0.0003435808,0.0003008596],"category_scores_gemma":[0.001033183,0.0001578967,0.0003314265,0.0001448924,0.000205458,0.00005173665,0.00005529361,0.000486209,0.00001054458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006898944,"about_ca_system_score_gemma":0.000135921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000611685,"about_ca_topic_score_gemma":8.811367e-7,"domain_scores_codex":[0.9982319,0.00003281326,0.0009135704,0.0002331306,0.0002569954,0.0003315895],"domain_scores_gemma":[0.9984499,0.0002003795,0.0003222704,0.0001494661,0.0005742387,0.0003037224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001363933,0.0009236977,0.003711817,0.0000885776,0.0001578319,0.0003675241,0.0003826953,0.000006685837,0.9916887,0.00000664312,0.000058767,0.001243102],"study_design_scores_gemma":[0.02361312,0.00541845,0.04753617,0.0009440052,0.0003568939,0.003272258,0.002672514,0.001888904,0.9129526,0.0001279209,0.0004722757,0.0007448931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972761,0.0002540329,0.00005070051,0.0005580222,0.0002926884,0.0002326465,0.00002164555,0.00001476772,0.001299455],"genre_scores_gemma":[0.9988725,0.00004966819,0.0002036508,0.0003357622,0.0002664711,0.00001036279,0.00002158859,0.0000136777,0.0002263746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07873613,"threshold_uncertainty_score":0.6438839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02766046713131438,"score_gpt":0.2618801651240973,"score_spread":0.234219697992783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}