{"id":"W2025643953","doi":"10.1074/jbc.m109.005611","title":"C1q Tumor Necrosis Factor α-related Protein Isoform 5 Is Increased in Mitochondrial DNA-depleted Myocytes and Activates AMP-activated Protein Kinase","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; Ministry of Education, Science and Technology; Korea Science and Engineering Foundation","keywords":"Protein kinase A; Gene isoform; Cell biology; Myocyte; Tumor necrosis factor alpha; ASK1; Protein kinase R; Kinase; Cancer research; Molecular biology; Chemistry; Biology; Mitogen-activated protein kinase kinase; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774724,0.0003300337,0.0008423207,0.00009592374,0.00006206927,0.00003446827,0.000161165,0.000419809,0.0006150258],"category_scores_gemma":[0.001142968,0.0002174141,0.0001950999,0.0003167658,0.0001280082,0.0001545085,0.0000409427,0.0008418447,0.000005754512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001042309,"about_ca_system_score_gemma":0.0001420158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000265077,"about_ca_topic_score_gemma":4.539174e-7,"domain_scores_codex":[0.9981242,0.00006364591,0.0008017197,0.0003204894,0.0002808986,0.000409087],"domain_scores_gemma":[0.9986098,0.00007307501,0.0005412921,0.0002031768,0.0001763847,0.0003962064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002256759,0.0004587965,0.001322465,0.00005523827,0.00007994727,0.0002437125,0.0001291933,9.348076e-8,0.9932899,0.000004115894,0.0001071596,0.002052653],"study_design_scores_gemma":[0.004367513,0.0007253324,0.03662523,0.000438039,0.00005252774,0.0003105047,0.0000597925,0.000005583302,0.9547782,0.0004408482,0.001952093,0.000244346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972654,0.0008031725,0.000006158747,0.00104323,0.00003790734,0.0005719569,0.00002167388,0.00004399405,0.0002064913],"genre_scores_gemma":[0.9979437,0.00005144088,0.001025778,0.0003115461,0.000298039,0.00001418608,0.00002099348,0.00001717579,0.0003171298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03851167,"threshold_uncertainty_score":0.8865889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105533262821512,"score_gpt":0.2629312325668112,"score_spread":0.241875899938596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}