{"id":"W2025664022","doi":"10.1016/j.bone.2009.12.005","title":"Functional analysis of a type 1 parathyroid hormone receptor intracellular tail mutant [KRK(484-6)AAA]: Effects on second messenger generation and cellular targeting","year":2009,"lang":"en","type":"article","venue":"Bone","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital; McGill University; Royal Ottawa Mental Health Centre; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Transfection; Intracellular; Cell biology; Green fluorescent protein; HEK 293 cells; Gq alpha subunit; Parathyroid hormone; Intracrine; G protein-coupled receptor; Second messenger system; Gs alpha subunit; Molecular biology; Receptor; Adenylyl cyclase; Signal transduction; Chemistry; Biochemistry; Paracrine signalling; Calcium; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002987096,0.0007004604,0.00051679,0.000279968,0.000404573,0.0004537915,0.0009444873,0.0008538028,0.003096744],"category_scores_gemma":[0.0003384231,0.0003261524,0.0005165686,0.0002356911,0.0006730683,0.0002915276,0.0003043924,0.0009453781,0.001100934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000633817,"about_ca_system_score_gemma":0.000492567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002854769,"about_ca_topic_score_gemma":0.002071422,"domain_scores_codex":[0.9997299,0.00004962235,0.00005445429,0.00005056498,0.00006456525,0.00005077393],"domain_scores_gemma":[0.9995261,0.0001313275,0.0001737783,0.00004046164,0.00003433689,0.00009403998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002996207,0.0000426816,0.00006510047,0.00002743938,0.00001088991,0.0001654327,0.00001963924,0.0002315098,0.9984212,0.0002801501,0.00004111117,0.0003954039],"study_design_scores_gemma":[0.00008778216,0.0001564618,0.001094162,0.000005604313,0.00003893282,0.0007657741,0.00003262133,0.002383538,0.9933639,0.00006756693,0.001983055,0.00002073025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929329,0.0003734811,0.003745326,0.0002084467,0.0001014874,0.00006329463,0.001358754,0.0001479004,0.001068415],"genre_scores_gemma":[0.9917468,0.0002781934,0.00365941,0.00008874864,0.00002287247,0.00005449903,0.001032563,0.000179202,0.002937787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003096744,"threshold_uncertainty_score":0.01035959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00882223346268321,"score_gpt":0.2126444387928217,"score_spread":0.2038222053301385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}