{"id":"W2025727558","doi":"10.1038/nsmb.2853","title":"RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation","year":2014,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"CTD; RNA polymerase II; Dephosphorylation; Transcription (linguistics); C-terminus; Phosphorylation; Cell biology; Chemistry; Eukaryotic transcription; RNA; Biology; Molecular biology; Biochemistry; Phosphatase; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004950003,0.0008949464,0.0005556433,0.0005439317,0.0005831976,0.0007387882,0.0005501626,0.0004527612,0.002755701],"category_scores_gemma":[0.0005494195,0.0005303255,0.0005918852,0.0002140322,0.0005856764,0.0004557382,0.000630768,0.000747324,0.003217114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006383394,"about_ca_system_score_gemma":0.0003238308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004320755,"about_ca_topic_score_gemma":0.0007576798,"domain_scores_codex":[0.9996938,0.00004197361,0.00002803607,0.0001083184,0.00007693375,0.0000509383],"domain_scores_gemma":[0.9996493,0.0000491236,0.0001012767,0.00005923572,0.00003091681,0.0001101982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006249335,0.00002383451,0.0005203289,0.00007428367,0.00001258418,0.0002073968,0.00002403042,0.0001874282,0.9904581,0.0006222137,0.0004880336,0.00675674],"study_design_scores_gemma":[0.0000403345,0.00009414479,0.003772918,0.000009735625,0.00001360859,0.0008388418,0.00002425582,0.001624055,0.9849454,0.000144381,0.008477109,0.00001520545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9372759,0.007543162,0.04387959,0.0003443694,0.0003552542,0.0001921683,0.002838189,0.00235681,0.005214407],"genre_scores_gemma":[0.9626415,0.0009375269,0.02453019,0.0001283085,0.00003881055,0.0001243678,0.006175822,0.00023389,0.005189654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002755701,"threshold_uncertainty_score":0.009218752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003685459925266792,"score_gpt":0.2994898715752458,"score_spread":0.2958044116499789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}