{"id":"W2025738710","doi":"10.1002/dvdy.20069","title":"Vertebrate <i>crossveinless 2</i> is secreted and acts as an extracellular modulator of the BMP signaling cascade","year":2004,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Biology; Cell biology; Extracellular; Cascade; Signal transduction; Bone morphogenetic protein; Genetics; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009664372,0.0001927988,0.0001398931,0.00002618466,0.0001622583,0.00003692148,0.0002659858,0.0001524665,0.00001144969],"category_scores_gemma":[0.00003153934,0.0001689511,0.00005869938,0.0001025911,0.0001583471,0.00001111307,0.0001864365,0.00008910569,0.000004219776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006416684,"about_ca_system_score_gemma":0.0003031652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003152924,"about_ca_topic_score_gemma":0.00007912145,"domain_scores_codex":[0.9989497,0.00003177298,0.0002497915,0.0003439157,0.0001926576,0.0002321605],"domain_scores_gemma":[0.9994596,0.000005937186,0.0001096884,0.0002447592,0.00005753225,0.0001224563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005966446,0.00008809085,0.009320066,0.00004559234,0.00007695956,0.000008397277,0.0005161701,0.0008501906,0.9881343,0.0003075763,0.00001115264,0.0005817885],"study_design_scores_gemma":[0.000717718,0.00006431423,0.006751594,0.00005876294,0.00002239562,0.00004639414,0.0003093638,0.001324686,0.9897045,0.0003037868,0.0004142455,0.0002822235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983556,0.00038591,0.0007744629,0.00003693091,0.0000947553,0.0001758122,0.00007093188,0.00001526996,0.00009030837],"genre_scores_gemma":[0.9968713,0.00001796876,0.002392225,0.0002883386,0.00003010249,0.000008238258,0.0001953078,0.00003468863,0.0001618588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002568473,"threshold_uncertainty_score":0.6889627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005819228878857326,"score_gpt":0.218746881009373,"score_spread":0.2129276521305157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}