{"id":"W2025748901","doi":"10.1016/j.biologicals.2009.08.016","title":"Characterization of variant diphtheria toxin–interleukin-3 fusion protein, DTIL3K116W, for phase I clinical trials","year":2009,"lang":"en","type":"article","venue":"Biologicals","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Diphtheria toxin; Diphtheria; Toxin; Microbiology; Medicine; Virology; Chemistry; Biology; Vaccination","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004026501,0.0002498074,0.001083225,0.00007345271,0.0001310771,0.00001826791,0.000327188,0.0007219649,0.001370883],"category_scores_gemma":[0.002120845,0.0001611573,0.0004645814,0.0001037756,0.0001389532,0.00007601777,0.0000572907,0.0002030894,0.00008647308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001756508,"about_ca_system_score_gemma":0.00004522652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003104281,"about_ca_topic_score_gemma":3.786576e-7,"domain_scores_codex":[0.9962626,0.001270747,0.001603021,0.0004596939,0.00003576895,0.0003682322],"domain_scores_gemma":[0.9981503,0.0004478592,0.0008553462,0.0003771909,0.0001318438,0.00003741663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001787422,0.0009868369,0.000008340641,0.000008279105,0.00008481877,0.000001873711,0.00003958152,8.014717e-8,0.9163921,0.00698533,0.0002275516,0.07347775],"study_design_scores_gemma":[0.005665886,0.007835488,0.002102259,0.00007698173,0.00006619146,0.00001382479,0.00003182482,0.00001393387,0.9269761,0.002942594,0.05401058,0.000264283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756665,0.0004906275,0.01936783,0.0005412198,0.001010196,0.002262899,0.000429457,0.0001014737,0.0001297935],"genre_scores_gemma":[0.9959506,0.0002195321,0.001165667,0.0006115946,0.0001727542,0.0001280188,0.000631162,0.00001307251,0.001107536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07321347,"threshold_uncertainty_score":0.999542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1115370008842609,"score_gpt":0.3937684916551069,"score_spread":0.2822314907708461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}