{"id":"W2025763389","doi":"10.1089/hum.2006.17.487","title":"Correction of Feline Lipoprotein Lipase Deficiency with Adeno-Associated Virus Serotype 1-Mediated Gene Transfer of the Lipoprotein Lipase S447X Beneficial Mutation","year":2006,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Dainippon Sumitomo Pharma","keywords":"Lipoprotein lipase; Lipase; Serotype; Mutation; Virology; Gene; Genetic enhancement; Biology; Genetics; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000539069,0.0003542083,0.0003657347,0.0001519371,0.0002613546,0.00002471721,0.0004487502,0.0003000253,0.000121994],"category_scores_gemma":[0.00004071851,0.0002752619,0.0002065706,0.0005894331,0.0002573501,0.00001184916,0.00004306598,0.0002432165,0.000005901862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000615763,"about_ca_system_score_gemma":0.0002701824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002082645,"about_ca_topic_score_gemma":0.008078507,"domain_scores_codex":[0.9974163,0.0003561519,0.0006220188,0.0005248698,0.0006307928,0.0004498497],"domain_scores_gemma":[0.9984294,0.00002480401,0.000282642,0.0007050578,0.0004803844,0.0000777293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004913584,0.0007497548,0.0002569201,0.00001838489,0.0001274428,0.000005655442,0.0001798035,0.003289083,0.9859604,0.000008009608,0.0001295822,0.004361426],"study_design_scores_gemma":[0.003115701,0.006914517,0.005508681,0.00003611089,0.00003825465,0.00001270847,0.00003780252,0.0002427601,0.9835501,0.00007278582,0.0001639875,0.0003066178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959431,0.0019179,0.0003856167,0.00006733827,0.0001583981,0.001220062,0.0001306877,0.00003629567,0.000140599],"genre_scores_gemma":[0.9979464,0.0002719635,0.00007716806,0.00009140974,0.0003517624,0.0001238708,0.0006063015,0.00009003803,0.0004410708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006164762,"threshold_uncertainty_score":0.99997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350715953197388,"score_gpt":0.2535930466997071,"score_spread":0.2400858871677332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}