{"id":"W2025797098","doi":"10.1021/ol901423c","title":"Exploring Side-Chain Diversity by Submonomer Solid-Phase Aza-Peptide Synthesis","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Chemistry; Peptide; Solid-phase synthesis; Side chain; Alkylation; Combinatorial chemistry; Peptide synthesis; Circular dichroism; Stereochemistry; Regioselectivity; Yield (engineering); Selectivity; Cyclic peptide; Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745345,0.0003772758,0.0003451319,0.0001540794,0.0001221127,0.0002933656,0.0002360989,0.000287642,0.001201455],"category_scores_gemma":[0.0002095334,0.0001336535,0.0001795781,0.0001795281,0.0002136096,0.0002471942,0.0001837935,0.0004999314,0.0005264357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251738,"about_ca_system_score_gemma":0.0001438024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001181061,"about_ca_topic_score_gemma":0.0002551436,"domain_scores_codex":[0.9999105,0.00001655257,0.000005432927,0.00002332664,0.00002497176,0.00001924012],"domain_scores_gemma":[0.9998425,0.00006330921,0.00004143103,0.00001540942,0.00001749744,0.0000197865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002316516,0.00001100278,0.00003077681,0.00002127907,0.00000259632,0.00002333547,0.000007290841,0.0002928378,0.9978758,0.0001348881,0.00001827656,0.001558658],"study_design_scores_gemma":[0.00001556938,0.0002087776,0.0001729433,0.000001928868,0.000006772877,0.00008252541,0.000004737804,0.00124975,0.9967452,0.00009116689,0.001417098,0.000003402931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661701,0.002024799,0.02806949,0.0001400113,0.00003749738,0.00009642995,0.0002661876,0.0002008502,0.00299446],"genre_scores_gemma":[0.9735364,0.00127282,0.0234254,0.0000505652,0.00001695095,0.00008427094,0.0002437338,0.00003815419,0.001331731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201455,"threshold_uncertainty_score":0.00401926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036373661747397,"score_gpt":0.2353209463995527,"score_spread":0.2149572097820787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}