{"id":"W2025807644","doi":"10.1007/s00125-013-2910-4","title":"Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice","year":2013,"lang":"en","type":"article","venue":"Diabetologia","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier de l’Université de Montréal; Hotel Dieu Hospital","funders":"Canadian Institutes of Health Research; American Society of Nephrology; Heart And Stroke Foundation Of Quebec; National Institutes of Health; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Endocrinology; Internal medicine; Kidney; Insulin; Downregulation and upregulation; Diabetes mellitus; Angiotensin II; Medicine; Biology; Blood pressure; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543909,0.000105801,0.0002092682,0.00008593623,0.00003296822,0.000011013,0.00004208844,0.0001474044,0.000005615557],"category_scores_gemma":[0.0001715402,0.00009239741,0.00002629731,0.00006196217,0.0001574982,0.00001239122,0.0001613531,0.00007170955,6.322422e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004724984,"about_ca_system_score_gemma":0.0000174979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008307258,"about_ca_topic_score_gemma":0.000005129994,"domain_scores_codex":[0.9991548,0.00009473271,0.0002268996,0.0002543876,0.00009059654,0.0001786005],"domain_scores_gemma":[0.9995722,0.00001188158,0.0000951517,0.0001345808,0.00007518192,0.0001110381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007469297,0.00003965469,0.01004822,0.00005993856,0.00001331221,0.000002837251,0.00002941802,0.000001999585,0.9824587,0.000001973712,0.00006994981,0.007199373],"study_design_scores_gemma":[0.0006298425,0.0005041099,0.08902856,0.0001030549,0.000008901367,0.00001039374,0.00001437231,0.000388082,0.9090797,0.0001223679,0.00001770354,0.00009288326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987593,0.0008069779,0.00002530787,0.00007835343,0.00001384465,0.0002865601,0.000018458,0.000004498212,0.000006656258],"genre_scores_gemma":[0.9977013,0.0008051028,0.001331262,0.00007000325,0.00001632621,0.00001090912,0.00004331228,0.00001211639,0.000009673671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07898034,"threshold_uncertainty_score":0.3767857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00936965042168339,"score_gpt":0.2206960235101658,"score_spread":0.2113263730884824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}