{"id":"W2025822934","doi":"10.1038/ncponc0736","title":"Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress","year":2007,"lang":"en","type":"review","venue":"Nature Clinical Practice Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":450,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jennerex Biotherapeutics (Canada)","funders":"","keywords":"Oncolytic virus; Virotherapy; Clinical trial; Third generation; Genetically engineered; First generation; Medicine; Cancer; Virology; Virus; Biology; Computer science; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009918838,0.001136915,0.004352965,0.001233934,0.0004270785,0.00380102,0.00223325,0.003720001,0.005212247],"category_scores_gemma":[0.01355021,0.000319095,0.001173996,0.001692466,0.001525844,0.003198399,0.0009209395,0.005568211,0.001935065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0016388,"about_ca_system_score_gemma":0.003139757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008369396,"about_ca_topic_score_gemma":0.001778861,"domain_scores_codex":[0.9980457,0.0007657445,0.0001997564,0.0001965528,0.0007074958,0.00008465529],"domain_scores_gemma":[0.9866465,0.01046452,0.0005857458,0.0002538388,0.001564789,0.0004846165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000692506,0.000185226,0.0003468441,0.009318362,0.0002507174,0.000218766,0.00008980467,0.0006089886,0.001216579,0.007667792,0.09953482,0.8798695],"study_design_scores_gemma":[0.0008996832,0.0008286491,0.00104186,0.01071085,0.0005006492,0.001211433,0.000120666,0.0004666458,0.000752885,0.01254759,0.9708502,0.00006877861],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002635016,0.9898931,0.0008503786,0.006007094,0.001219926,0.00003072113,0.00007174013,0.00002710954,0.001636436],"genre_scores_gemma":[0.00227978,0.9859104,0.001576404,0.007193101,0.001793615,0.00006543821,0.0001310928,0.0000200701,0.001030105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009918838,"threshold_uncertainty_score":0.05245644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1367214556529142,"score_gpt":0.5712438850854086,"score_spread":0.4345224294324943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}