{"id":"W2025822934","doi":"10.1038/ncponc0736","title":"Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress","year":2007,"lang":"en","type":"review","venue":"Nature Clinical Practice Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":450,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jennerex Biotherapeutics (Canada)","funders":"","keywords":"Oncolytic virus; Virotherapy; Clinical trial; Third generation; Genetically engineered; First generation; Medicine; Cancer; Virology; Virus; Biology; Computer science; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.01802399,0.0007525017,0.004499401,0.0002856794,0.00007211788,0.00001965727,0.001473201,0.00816509,0.00003077758],"category_scores_gemma":[0.02151125,0.0005400933,0.001656076,0.000749146,0.002024906,0.00001664594,0.0003835579,0.006246582,0.00001880379],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429387,"about_ca_system_score_gemma":0.008483452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000678114,"about_ca_topic_score_gemma":0.0001061589,"domain_scores_codex":[0.9840432,0.006917935,0.005512902,0.001768395,0.0009710426,0.0007864943],"domain_scores_gemma":[0.98062,0.009685221,0.006049223,0.001948607,0.001243555,0.0004533461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3397187,0.004179251,0.00001003566,0.001189922,0.001649352,0.0001067724,0.0000103868,2.156915e-7,0.00001430385,0.00002156993,0.001694033,0.6514055],"study_design_scores_gemma":[0.04115003,0.09594058,0.000009379321,0.001356314,0.001406544,0.0001268358,0.00002841582,9.426158e-7,0.00007563439,0.000007569372,0.8594567,0.0004410439],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001435563,0.9881532,0.00002060762,0.0004302695,0.001370561,0.005504137,0.0001618586,0.00002222314,0.002901609],"genre_scores_gemma":[0.0002820012,0.987043,0.007688183,0.0007200026,0.003245806,0.0002401086,0.0003491161,0.0001712409,0.0002605724],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8577627,"threshold_uncertainty_score":0.9997051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1367214556529142,"score_gpt":0.5712438850854086,"score_spread":0.4345224294324943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}