{"id":"W2025834688","doi":"10.1016/j.neuroscience.2008.11.004","title":"Calcineurin inhibition eliminates the normal inverted U curve, enhances acquisition and prolongs memory in a mammalian 3′-5′-cyclic AMP–dependent learning paradigm","year":2008,"lang":"en","type":"article","venue":"Neuroscience","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Calcineurin; Neuroscience; CREB; Long-term potentiation; Dephosphorylation; Phosphatase; Conditioned place preference; Hippocampal formation; Chemistry; Psychology; Phosphorylation; Biochemistry; Medicine; Internal medicine; Transcription factor; Receptor; Transplantation; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003214528,0.0007613385,0.0007311539,0.0008966983,0.0004466335,0.0007212256,0.001503089,0.000707312,0.003214051],"category_scores_gemma":[0.0006632737,0.000331255,0.0005985116,0.0004352244,0.00118362,0.001062648,0.0005645628,0.003027095,0.0007568349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008270974,"about_ca_system_score_gemma":0.001071329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00213859,"about_ca_topic_score_gemma":0.003472522,"domain_scores_codex":[0.999587,0.00003682735,0.00004178477,0.00008387252,0.0001182369,0.0001322238],"domain_scores_gemma":[0.9988465,0.0001983108,0.0003007356,0.0002577114,0.00008310759,0.0003135192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007231589,0.0003019547,0.000111194,0.00003370548,0.00001083502,0.00008573212,0.00004289352,0.000120319,0.9937575,0.0005695528,0.0001654033,0.004077867],"study_design_scores_gemma":[0.00004990406,0.0007684685,0.001431146,0.000008005555,0.00001526351,0.0001477182,0.00003384396,0.001044049,0.9952551,0.0003880144,0.0008435273,0.00001482993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931024,0.0006308381,0.002491746,0.0002912,0.0001404947,0.00003437579,0.0002688361,0.0004087375,0.002631385],"genre_scores_gemma":[0.9890862,0.0006367945,0.0033567,0.0001442558,0.00005102811,0.00006862479,0.0003996995,0.0001784111,0.00607826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003214051,"threshold_uncertainty_score":0.01075208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819280636677905,"score_gpt":0.2493022768038014,"score_spread":0.2311094704370224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}