{"id":"W2025836097","doi":"10.1182/blood-2011-01-330019","title":"A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Haematopoiesis; Leukemia; In vivo; Myeloid leukemia; Stem cell; Progenitor cell; Myeloid; CD34; Cancer research; Biology; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076214,0.0001525413,0.0001224751,0.00004528423,0.00009528651,0.00001671483,0.0002594267,0.00009926691,0.00001758993],"category_scores_gemma":[0.000008519379,0.0001082233,0.00007087979,0.0001130359,0.0001261428,0.000002579733,0.00005204984,0.0001467767,0.000008632253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001718688,"about_ca_system_score_gemma":0.0001072029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001913402,"about_ca_topic_score_gemma":0.00004873225,"domain_scores_codex":[0.9989232,0.0001511587,0.0001877615,0.0002918098,0.0002144642,0.000231539],"domain_scores_gemma":[0.9992611,0.00002604882,0.0001148611,0.0004574839,0.00008477234,0.00005573204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001903864,0.0002234209,0.000444128,0.00001493214,0.0001125866,0.000007832267,0.0001487106,0.0005179932,0.997623,0.00007319181,0.00005784303,0.0005860378],"study_design_scores_gemma":[0.001611231,0.001270221,0.001321985,0.00003240979,0.00005447837,0.000006272831,0.00009750058,0.0000113112,0.9952675,0.000004810449,0.0001899716,0.0001322701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959325,0.0001060426,0.0004031299,0.000009696807,0.00001538494,0.0002927682,0.000009551358,0.0000113764,0.003219617],"genre_scores_gemma":[0.9991832,0.000009147654,0.0002308395,0.00004074639,0.0000589568,0.00001963267,0.00003088542,0.00003186701,0.0003947158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003250776,"threshold_uncertainty_score":0.4413217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06034523864199982,"score_gpt":0.2729055264247293,"score_spread":0.2125602877827295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}