{"id":"W2025836097","doi":"10.1182/blood-2011-01-330019","title":"A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Haematopoiesis; Leukemia; In vivo; Myeloid leukemia; Stem cell; Progenitor cell; Myeloid; CD34; Cancer research; Biology; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694293,0.000798351,0.0005265536,0.0005516599,0.0002725839,0.0003170668,0.0003265575,0.0003218815,0.001838755],"category_scores_gemma":[0.0002400576,0.0001808057,0.0002882119,0.0005039349,0.0003017909,0.0001967375,0.0002327487,0.0005309299,0.0006259054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006622296,"about_ca_system_score_gemma":0.0005224486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001949861,"about_ca_topic_score_gemma":0.005341642,"domain_scores_codex":[0.9997979,0.0000390074,0.00001657858,0.00005531125,0.00005747063,0.00003382977],"domain_scores_gemma":[0.9998809,0.00002053616,0.00002678787,0.00002054303,0.00003232255,0.00001882334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422172,0.0002252673,0.0004617356,0.0001132012,0.00001886638,0.00008491237,0.00004074672,0.0009035712,0.9852997,0.0001767705,0.0002507456,0.01218224],"study_design_scores_gemma":[0.0001204618,0.00407544,0.002584903,0.00001232799,0.0000564138,0.0002735101,0.00002618556,0.000874518,0.9872457,0.00005309617,0.004661457,0.00001598851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700807,0.003551991,0.01453959,0.0002591069,0.00003723126,0.0009776424,0.003219341,0.0005549327,0.006779592],"genre_scores_gemma":[0.9764214,0.003867381,0.01142651,0.0001144086,0.00001005441,0.0003560208,0.002728707,0.0000680048,0.005007592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949861,"threshold_uncertainty_score":0.006151199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06034523864199982,"score_gpt":0.2729055264247293,"score_spread":0.2125602877827295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}