{"id":"W2025845768","doi":"10.1371/journal.pone.0052128","title":"Evidence for a Novel Mechanism Independent of Myocardial Iron in β-Thalassemia Cardiac Pathogenesis","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Thalassemia; Medicine; Internal medicine; Hemoglobinopathy; Hereditary hemochromatosis; Cardiology; Beta thalassemia; Heart failure; Muscle hypertrophy; Pathophysiology; Anemia; Chelation therapy; Contractility; Ineffective erythropoiesis; Hemolytic anemia; Hemochromatosis; Erythropoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004945528,0.0001357774,0.0004783763,0.0001165594,0.00002758213,0.000004027093,0.0000697145,0.0002225736,0.0000237033],"category_scores_gemma":[0.0003746419,0.000120787,0.000158589,0.0001746669,0.00002825194,0.00009929424,0.00004585783,0.0001608536,0.00001353791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009613577,"about_ca_system_score_gemma":0.00008977946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006392486,"about_ca_topic_score_gemma":0.000003261484,"domain_scores_codex":[0.9986956,0.00003346081,0.0003052686,0.0001932113,0.0004082094,0.0003642188],"domain_scores_gemma":[0.9992795,0.0001369833,0.00008792707,0.0002535238,0.00009249116,0.0001495696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003078952,0.002362926,0.1036096,0.0006597818,0.0002830337,0.000003011782,0.0007442607,0.000003811353,0.8902882,0.0004993448,0.00004751431,0.001190638],"study_design_scores_gemma":[0.00820054,0.001519435,0.3862183,0.005303214,0.003485202,0.00001734906,0.001885792,0.0007348323,0.5913949,0.000265231,0.0002274893,0.0007476356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938866,0.003950467,0.0003048337,0.0003131776,0.0001613943,0.0009767048,0.0000319762,0.00002580848,0.0003490137],"genre_scores_gemma":[0.9955039,0.001114946,0.002805014,0.00009684212,0.0001777959,0.0001262445,0.00001254582,0.00002925559,0.0001334762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2988933,"threshold_uncertainty_score":0.4925551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07027573878938369,"score_gpt":0.2727654869281216,"score_spread":0.2024897481387379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}