{"id":"W2025869159","doi":"10.1111/j.1742-4658.2006.05193.x","title":"Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs","year":2006,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Calmodulin; Nitric oxide synthase; Endothelial NOS; Biochemistry; Chemistry; Enzyme; Mutant; Cytosol; Isozyme; Linker; Nitric oxide; Nitric Oxide Synthase Type III; Binding site; Binding domain; Enos; Molecular biology; Biophysics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725066,0.0002662463,0.0002688597,0.00008518543,0.0001438493,0.0001611798,0.0002696233,0.0002829304,0.0006167029],"category_scores_gemma":[0.0002583042,0.0001228502,0.0001977082,0.00007884939,0.0001508367,0.0001529133,0.0002097193,0.0003362588,0.0001814807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003227475,"about_ca_system_score_gemma":0.00009565076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004771363,"about_ca_topic_score_gemma":0.000731086,"domain_scores_codex":[0.9998066,0.00005696003,0.00001323843,0.00004080003,0.00003953336,0.0000428832],"domain_scores_gemma":[0.9998797,0.0000434222,0.00002468057,0.00001421592,0.00001405682,0.00002387876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006297175,0.00001379579,0.0001524624,0.00001417321,0.000002606117,0.00002047107,0.000005709691,0.00005656677,0.9991627,0.0000440534,0.00001267081,0.0004517905],"study_design_scores_gemma":[0.00002558688,0.00009261427,0.005444739,0.000004302954,0.000005938955,0.0001388942,0.00001185197,0.002031327,0.9912081,0.00007024762,0.0009620319,0.000004279497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961913,0.0009866944,0.002030384,0.00005230379,0.0000191432,0.00001391395,0.00004978459,0.0000126874,0.0006438344],"genre_scores_gemma":[0.995939,0.0004414683,0.00265308,0.00005168637,0.000008363877,0.00002079603,0.0001824197,0.000006669995,0.0006965108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006167029,"threshold_uncertainty_score":0.002341688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00956418629534739,"score_gpt":0.2424154728974778,"score_spread":0.2328512866021304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}