{"id":"W2025871074","doi":"10.1016/j.bpj.2011.11.3683","title":"hERG Quality Control at the Plasma Membrane","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"hERG; TSG101; Endosome; Cell biology; Chemistry; Mutant; Endoplasmic reticulum; Internalization; Intracellular; Biochemistry; Potassium channel; Biology; Biophysics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000945857,0.0002726304,0.0004373257,0.0003478704,0.0003804474,0.002562312,0.0006356454,0.0006855531,0.002501815],"category_scores_gemma":[0.002395939,0.0002157798,0.0002093466,0.0003057941,0.0004999809,0.001501212,0.0006716205,0.0006715968,0.000647014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009173999,"about_ca_system_score_gemma":0.0003034755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012718,"about_ca_topic_score_gemma":0.0006819984,"domain_scores_codex":[0.9995029,0.0001198935,0.00002295493,0.0001362715,0.0001383012,0.00007956246],"domain_scores_gemma":[0.9991155,0.0002750558,0.0001106541,0.0001293351,0.0002977706,0.00007167659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007212052,0.00006608788,0.005781498,0.0001930011,0.00008149145,0.0004805082,0.0004027552,0.01118026,0.8480595,0.04111451,0.00324459,0.08867461],"study_design_scores_gemma":[0.0002992562,0.0005844653,0.07087138,0.0001435025,0.0001269614,0.002304302,0.0006117164,0.374211,0.4511231,0.0782361,0.02131542,0.0001728099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5677739,0.01140699,0.3928546,0.004566777,0.0005116296,0.0001018714,0.0008726231,0.00108549,0.02082614],"genre_scores_gemma":[0.9856522,0.0009413767,0.01026137,0.0001745877,0.0001228599,0.00001155682,0.0001725615,0.0001523469,0.002511121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562312,"threshold_uncertainty_score":0.008369386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701432247431898,"score_gpt":0.2915685055589058,"score_spread":0.2745541830845868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}