{"id":"W2025878105","doi":"10.1016/j.vaccine.2003.09.023","title":"Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA)","year":2003,"lang":"en","type":"article","venue":"Vaccine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"National Cancer Institute","keywords":"DNA vaccination; Plasmid; Vaccination; Adjuvant; Antigen; Biology; Carcinoembryonic antigen; Immunity; Immune system; Virology; DNA; Microbiology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002732672,0.001165812,0.0005009959,0.0008398664,0.0002450226,0.0005826628,0.0003897981,0.0006615676,0.003169412],"category_scores_gemma":[0.0004807443,0.0004825369,0.0005475148,0.0005454274,0.0005756837,0.0004585043,0.0005882664,0.001939818,0.001750173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006996879,"about_ca_system_score_gemma":0.0004586238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006562493,"about_ca_topic_score_gemma":0.0008724141,"domain_scores_codex":[0.9995883,0.0000899266,0.00002532552,0.00005557007,0.00009833573,0.000142528],"domain_scores_gemma":[0.9994629,0.0002363736,0.0001129725,0.00006724552,0.00003594077,0.00008456136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002141081,0.00006770148,0.0001115013,0.00004140466,0.000009234912,0.0000256668,0.00001174713,0.0001352715,0.9976418,0.0002578425,0.0001055373,0.001378196],"study_design_scores_gemma":[0.00005424412,0.0002988521,0.0006198375,0.000005254996,0.00002676027,0.00007193508,0.000008727989,0.0007450402,0.9959787,0.0000970687,0.00208953,0.000004088608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958587,0.00162005,0.03077421,0.0005625436,0.0004337422,0.0003193507,0.001212566,0.0009923719,0.00549808],"genre_scores_gemma":[0.9619836,0.0008670675,0.02311075,0.0001414031,0.0001217664,0.0002573566,0.002725356,0.0001649403,0.0106278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169412,"threshold_uncertainty_score":0.01060277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01836571002098906,"score_gpt":0.2520403140695034,"score_spread":0.2336746040485144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}