{"id":"W2025878105","doi":"10.1016/j.vaccine.2003.09.023","title":"Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA)","year":2003,"lang":"en","type":"article","venue":"Vaccine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"National Cancer Institute","keywords":"DNA vaccination; Plasmid; Vaccination; Adjuvant; Antigen; Biology; Carcinoembryonic antigen; Immunity; Immune system; Virology; DNA; Microbiology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006142391,0.0004663354,0.0006013293,0.0003566013,0.0006154014,0.0000674881,0.000396393,0.0004252178,0.003586557],"category_scores_gemma":[0.0003169447,0.0003882307,0.0001970246,0.000381141,0.00003392979,0.0003408458,0.00007000328,0.0004902994,0.0006575947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597448,"about_ca_system_score_gemma":0.0002545325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004637636,"about_ca_topic_score_gemma":0.00004768914,"domain_scores_codex":[0.9972799,0.000591706,0.0006552002,0.0005518485,0.00008801428,0.0008333666],"domain_scores_gemma":[0.9985363,0.0003951763,0.0002546546,0.0006358681,0.0001328269,0.00004517677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002926224,0.0002246837,0.005491642,0.00004884898,0.0005413711,0.00003214515,0.0007756473,0.0003511677,0.9815497,0.0004383668,0.002080152,0.005540048],"study_design_scores_gemma":[0.009202149,0.0009065584,0.06798,0.00008888872,0.00009297369,0.0002094205,0.00052863,0.00006955233,0.7326049,0.00002813785,0.1876063,0.0006825481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900616,0.004535149,0.0001585546,0.0001792875,0.001844112,0.0005520531,0.00005746149,0.000204902,0.002406876],"genre_scores_gemma":[0.9860511,0.001357478,0.00007249494,0.0002446648,0.00006226221,0.0000291136,0.0001863113,0.00007346507,0.01192304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2489448,"threshold_uncertainty_score":0.9998569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01836571002098906,"score_gpt":0.2520403140695034,"score_spread":0.2336746040485144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}