{"id":"W2025881245","doi":"10.1007/s00011-004-1273-1","title":"Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits","year":2004,"lang":"en","type":"article","venue":"Inflammation Research","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Surgical Specialties (Canada)","funders":"","keywords":"Paclitaxel; Biocompatibility; Microsphere; Arthritis; PLGA; Carrageenan; Pharmacology; Biomedical engineering; Chemistry; Medicine; Surgery; In vitro; Immunology; Chemotherapy; Chemical engineering; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267433,0.0008849882,0.0008119289,0.001125728,0.0004753094,0.0004893848,0.0007328501,0.001111691,0.0008466682],"category_scores_gemma":[0.0007564804,0.0005588146,0.0009980068,0.0006656947,0.0008042101,0.0008753764,0.0002456745,0.001248646,0.0005600714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004040653,"about_ca_system_score_gemma":0.0006052329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002340925,"about_ca_topic_score_gemma":0.002888338,"domain_scores_codex":[0.9992003,0.0001497557,0.0001071773,0.0001514012,0.0001462902,0.0002451591],"domain_scores_gemma":[0.9988394,0.0003009969,0.0003621272,0.0002022265,0.0001433675,0.0001519346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002168314,0.0007747579,0.0001589457,0.00007759035,0.00001658061,0.00007481972,0.0001210728,0.0002261108,0.9932235,0.0001010384,0.000057643,0.002999648],"study_design_scores_gemma":[0.00008552815,0.0049913,0.0005477193,0.000003602546,0.00005049926,0.00005616594,0.00002451196,0.0003451592,0.9934877,0.00002676839,0.0003712114,0.000009868411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895774,0.002472207,0.005724075,0.0001644398,0.000121465,0.0001476012,0.0003900743,0.0001448822,0.001257857],"genre_scores_gemma":[0.9863567,0.002765966,0.0053645,0.0000618184,0.00007997484,0.0001381786,0.000397755,0.00006131779,0.004773718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002340925,"threshold_uncertainty_score":0.0067029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1398696963717466,"score_gpt":0.4726762484081481,"score_spread":0.3328065520364015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}