{"id":"W2025891700","doi":"10.1016/s0027-5107(01)00297-4","title":"Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum","year":2002,"lang":"en","type":"article","venue":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"MSH2; DNA mismatch repair; Biology; Carcinogenesis; Mutation; Mutation frequency; Microsatellite instability; Lymphoma; Genetics; Gene; Cancer research; Molecular biology; DNA repair; Microsatellite; Immunology; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251864,0.0002732763,0.0001752295,0.000851027,0.0001365847,0.0003131447,0.0001154243,0.0002279098,0.00179113],"category_scores_gemma":[0.0002250598,0.0001593294,0.0001209708,0.0002428165,0.0002064581,0.0001386414,0.0001881491,0.0004369067,0.0004691247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001163328,"about_ca_system_score_gemma":0.00006675776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001248982,"about_ca_topic_score_gemma":0.0001845607,"domain_scores_codex":[0.9998197,0.00003117058,0.00001318522,0.00003770518,0.0000650732,0.00003311891],"domain_scores_gemma":[0.9995908,0.00008835012,0.0001355422,0.00004904265,0.00003110314,0.0001051796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006540241,0.00001134372,0.001150174,0.000008450105,0.000004198133,0.000105962,0.00001051494,0.00001418705,0.9972878,0.00005517728,0.00002564167,0.001261245],"study_design_scores_gemma":[0.00003242014,0.0002452875,0.0599455,0.000008721036,0.00004048836,0.005485509,0.00005654274,0.0004872898,0.9312018,0.0002121351,0.002275927,0.000008421627],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941096,0.00058898,0.003130602,0.00005234334,0.00001322711,0.00001172603,0.0002783777,0.0001550841,0.001660065],"genre_scores_gemma":[0.9969668,0.0003121327,0.001037508,0.00002556347,0.00001058795,0.00001428404,0.0002611616,0.00002908719,0.001342985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179113,"threshold_uncertainty_score":0.005991876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03235289062659365,"score_gpt":0.3234984013174559,"score_spread":0.2911455106908623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}