{"id":"W2025923829","doi":"10.1159/000381423","title":"Cystic Fibrosis from Laboratory to Bedside: The Role of A20 in NF-&amp;#954;B-Mediated Inflammation","year":2015,"lang":"en","type":"review","venue":"Medical Principles and Practice","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Inflammation; Gene silencing; Transcription factor; Cystic fibrosis; Proinflammatory cytokine; Tumor necrosis factor alpha; NF-κB; Immune system; Immunology; NFKB1; Fibrosis; Cancer research; Internal medicine; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002589482,0.0002665965,0.0006479075,0.00006847239,0.0000431738,0.00003180385,0.0003862788,0.0005704288,0.00005015947],"category_scores_gemma":[0.01904359,0.0001873151,0.00008457222,0.0002587127,0.0001107486,0.00001062192,0.0003681032,0.0004479925,0.0000486845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003854204,"about_ca_system_score_gemma":0.001039194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000223798,"about_ca_topic_score_gemma":0.0002378464,"domain_scores_codex":[0.9971547,0.0009873301,0.0006866541,0.0004143769,0.0005377782,0.0002192266],"domain_scores_gemma":[0.9971339,0.001435759,0.0004744521,0.0005039545,0.000195186,0.0002567371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003517018,0.0002039488,0.00009596445,0.00278653,0.0004215382,0.00003739875,0.0008728339,0.00002860564,0.009624023,0.0002642438,0.001803517,0.9835097],"study_design_scores_gemma":[0.0002112489,0.00009203142,0.00001342608,0.001439407,0.0002281486,0.00001651817,0.00007368316,0.00001849487,0.000332523,0.00003652668,0.9973368,0.0002012023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00321234,0.9948484,0.0001696658,0.0003829133,0.0001414365,0.0005036704,0.0002425799,0.00001105293,0.0004879815],"genre_scores_gemma":[0.0007982517,0.9957967,0.00140409,0.0002738959,0.0006107105,0.00009543521,0.0009221795,0.00004540435,0.00005335371],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9955333,"threshold_uncertainty_score":0.9892194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04353933349865782,"score_gpt":0.3414829236434279,"score_spread":0.2979435901447701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}