{"id":"W2025932643","doi":"10.1074/jbc.m312407200","title":"RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"RGS2; Heterotrimeric G protein; G protein; Regulator of G protein signaling; G protein-coupled receptor; Cell biology; GTPase-activating protein; Gq alpha subunit; Biology; Muscarinic acetylcholine receptor; GTPase; GTP-binding protein regulators; Chemistry; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007942431,0.000269395,0.00036027,0.00003613836,0.0001478696,0.0000671187,0.0004267347,0.0003442735,0.00009387158],"category_scores_gemma":[0.0004386871,0.0001695996,0.0001985726,0.0002136817,0.00006634069,0.000007906784,0.0002081763,0.0004151716,0.000009808741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005629031,"about_ca_system_score_gemma":0.00009230729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006105705,"about_ca_topic_score_gemma":0.000001251511,"domain_scores_codex":[0.9984058,0.00006728408,0.0005225908,0.0004062812,0.0002222465,0.0003758589],"domain_scores_gemma":[0.9988971,0.00003771607,0.0002492853,0.0002259698,0.0002474688,0.0003424146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002697991,0.00006914396,0.0001242023,0.00001168259,0.00008523321,0.00001097434,0.00007802907,0.002487104,0.9948287,0.000008989285,0.0002612924,0.001764835],"study_design_scores_gemma":[0.0005614144,0.0006972118,0.0001428935,0.0000602094,0.00002429846,0.0001474973,0.000142855,0.00001521046,0.9879341,0.0001431066,0.009880519,0.0002507513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906427,0.001328979,0.006406523,0.001162408,0.0001651999,0.0001573938,0.00001314422,0.00001183289,0.0001118146],"genre_scores_gemma":[0.9934202,0.0003525883,0.004325837,0.0006667118,0.0009758237,0.000008794315,0.00001413033,0.00002170034,0.0002141927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009619227,"threshold_uncertainty_score":0.6916072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437068844713051,"score_gpt":0.2408991204480991,"score_spread":0.2265284320009686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}