{"id":"W2025932643","doi":"10.1074/jbc.m312407200","title":"RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"RGS2; Heterotrimeric G protein; G protein; Regulator of G protein signaling; G protein-coupled receptor; Cell biology; GTPase-activating protein; Gq alpha subunit; Biology; Muscarinic acetylcholine receptor; GTPase; GTP-binding protein regulators; Chemistry; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398569,0.0004402967,0.0002450464,0.0001083234,0.000113097,0.0002228388,0.0002144448,0.0003482917,0.001842221],"category_scores_gemma":[0.0001179985,0.0001228104,0.0004949895,0.00009118453,0.0001797594,0.0001510543,0.0002623061,0.0003541003,0.0007578315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357761,"about_ca_system_score_gemma":0.0001706094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005276516,"about_ca_topic_score_gemma":0.0006585229,"domain_scores_codex":[0.9998462,0.00003003079,0.00001327046,0.00003220801,0.00003103173,0.00004735183],"domain_scores_gemma":[0.9999363,0.000008389266,0.00001889862,0.00001160083,0.000005104961,0.00001960537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005591878,0.000007143099,0.0001628793,0.00001259332,0.000003277811,0.00004294361,0.000005374172,0.00002703233,0.9993818,0.0000422019,0.00002524672,0.0002336496],"study_design_scores_gemma":[0.00003405061,0.0002108228,0.006474024,0.00000634453,0.0000139666,0.0006079819,0.00001817365,0.0005505308,0.9882338,0.00002559134,0.003820206,0.000004343813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956403,0.0008347057,0.001200407,0.0001056686,0.00002202011,0.00001792274,0.0001860922,0.00003666369,0.001956163],"genre_scores_gemma":[0.9927192,0.0006135286,0.002266767,0.0001760529,0.00002005243,0.00002761939,0.0008113239,0.00002273331,0.003342828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842221,"threshold_uncertainty_score":0.006162882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437068844713051,"score_gpt":0.2408991204480991,"score_spread":0.2265284320009686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}