{"id":"W2025962058","doi":"10.1016/j.chom.2013.09.009","title":"Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis","year":2013,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":188,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"SAMHD1; Biology; IRF3; Myeloid leukemia; Virology; Apoptosis; Leukemia; Reverse transcriptase; Sting; Innate immune system; Transcription factor; Virus; K562 cells; Immunology; Gene; Immune system; Genetics; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00008784719,0.0003800632,0.0004859949,0.0002521499,0.000456054,0.00002885008,0.0002182184,0.0005302703,0.0009250168],"category_scores_gemma":[0.00005503438,0.0003338886,0.0001654224,0.0003897661,0.0002689445,0.0001601491,0.0001566106,0.0004958585,0.002680033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001945332,"about_ca_system_score_gemma":0.00007495852,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009297198,"about_ca_topic_score_gemma":0.0001824987,"domain_scores_codex":[0.9982569,0.0001353596,0.00054677,0.000464675,0.00005441698,0.0005418724],"domain_scores_gemma":[0.9987234,0.0001721086,0.0004171787,0.0003516019,0.000286231,0.00004949439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005268533,0.0002446417,0.01612313,0.0000987782,0.0001037058,6.126215e-7,0.0004013305,0.000004434952,0.972412,0.00000317528,0.01008226,0.0004732028],"study_design_scores_gemma":[0.0009935269,0.0005157967,0.05107649,0.00003552133,0.00008772128,0.00000348511,0.0001101803,0.000002509164,0.9343139,0.000009258842,0.01251512,0.000336487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906806,0.004039573,0.00005192176,0.00002225584,0.00143298,0.0004710042,0.00007469448,0.0001726219,0.003054369],"genre_scores_gemma":[0.9928831,0.002150543,0.00004963026,0.00007009302,0.00008173337,0.00002658697,0.000236274,0.00004721069,0.004454869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03809814,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556135830611951,"score_gpt":0.2252538554684952,"score_spread":0.2096924971623757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}