{"id":"W2025975691","doi":"10.1007/s12307-008-0006-3","title":"A Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment","year":2008,"lang":"en","type":"article","venue":"Cancer Microenvironment","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique; Institute of Cancer Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Tumor microenvironment; Hypoxia (environmental); Cellular adaptation; Transcription factor; Hypoxia-inducible factors; Oxygen tension; Cell biology; Tumor hypoxia; Cancer research; Extracellular matrix; Biology; HIF1A; Chemistry; Medicine; Angiogenesis; Internal medicine; Gene; Oxygen; Tumor cells; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036448,0.0003904494,0.0008389366,0.0004460198,0.0005450807,0.0030511,0.0004468914,0.001573442,0.001060099],"category_scores_gemma":[0.0005742539,0.0001779413,0.0002321455,0.0004194757,0.002717485,0.003309093,0.00120067,0.003694434,0.0004864146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009765537,"about_ca_system_score_gemma":0.001218301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003777706,"about_ca_topic_score_gemma":0.0004228659,"domain_scores_codex":[0.9994979,0.0002102756,0.00002260256,0.00005225791,0.0001417886,0.00007514661],"domain_scores_gemma":[0.9995608,0.0001912193,0.00004680715,0.00002236494,0.00006819558,0.0001106013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003130586,0.0001075406,0.001822534,0.002945879,0.0001045535,0.003295355,0.004232134,0.001393028,0.1046825,0.4456581,0.05373731,0.3817081],"study_design_scores_gemma":[0.0000183203,0.0003037868,0.0032157,0.0008679595,0.00004227123,0.005147202,0.002533265,0.0006024336,0.01337296,0.1596299,0.814202,0.00006418296],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01359876,0.8662605,0.02000876,0.0813615,0.003604133,0.00001829812,0.00005263703,0.00009043127,0.01500498],"genre_scores_gemma":[0.1594713,0.7885057,0.01274384,0.01654799,0.0105618,0.00006809033,0.00006742361,0.00006441471,0.01196949],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0030511,"threshold_uncertainty_score":0.007085383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451475093426372,"score_gpt":0.2175070695526381,"score_spread":0.2029923186183744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}