{"id":"W2026027490","doi":"10.1002/eji.201040983","title":"An intrinsic B‐cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice","year":2010,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Arthritis Research Centre of Canada; University of Toronto","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Biology; Congenic; Autoimmunity; B cell; Immunology; B-cell receptor; Autoantibody; Antigen; Antibody; Transgene; B-1 cell; T cell; Immune system; Molecular biology; Cell biology; Genetics; Antigen-presenting cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00184694,0.0004915998,0.000947267,0.0006912798,0.0001880378,0.00004779273,0.001520886,0.0004484545,0.002547459],"category_scores_gemma":[0.0001959768,0.0004353941,0.000362701,0.0003457901,0.001084599,0.0003699168,0.0002905352,0.003659247,0.002148711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006790522,"about_ca_system_score_gemma":0.0005432211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003103902,"about_ca_topic_score_gemma":0.0003352502,"domain_scores_codex":[0.9944133,0.002638394,0.001474519,0.0004519229,0.00007383364,0.0009480124],"domain_scores_gemma":[0.9974646,0.0002892907,0.001013648,0.0008977349,0.0002249235,0.0001098354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007163503,0.000689605,0.005516001,0.000009568879,0.0003567064,0.0007642612,0.001589075,0.00000940864,0.9761405,0.00008387592,0.003526756,0.0105979],"study_design_scores_gemma":[0.01863753,0.006811659,0.1515729,0.0001020187,0.0003018203,0.01261204,0.0009284865,0.000002824127,0.5456007,0.000355744,0.261939,0.001135158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872813,0.00487869,0.00003200745,0.0004411869,0.004138943,0.0002058378,0.000009844013,0.00007341249,0.002938802],"genre_scores_gemma":[0.9925214,0.0006516819,0.0002042529,0.0002286036,0.0002209773,0.000001131845,0.00005830053,0.00008298158,0.006030674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4305398,"threshold_uncertainty_score":0.9998098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00796751288858915,"score_gpt":0.2123361308225634,"score_spread":0.2043686179339743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}