{"id":"W2026042453","doi":"10.1080/01635580903441238","title":"Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells Is Caspase-Independent and Involves Cellular Ceramide Accumulation and Damage to Mitochondria","year":2010,"lang":"en","type":"article","venue":"Nutrition and Cancer","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Curcumin; Apoptosis; Ceramide; Chemistry; Cytochrome c; Cytotoxicity; Glutathione; Caspase 3; Mitochondrion; Biochemistry; p38 mitogen-activated protein kinases; Programmed cell death; Cell biology; Kinase; MAPK/ERK pathway; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007249915,0.0001360942,0.0001222905,0.00007748781,0.00007681199,0.00005058998,0.00005907745,0.0001758743,0.00002471389],"category_scores_gemma":[0.00001161165,0.0001280688,0.00002093716,0.0001117762,0.00007533687,0.00001116617,0.00007538711,0.0001315465,0.000002140324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001571229,"about_ca_system_score_gemma":0.00003117946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004157981,"about_ca_topic_score_gemma":0.0005808669,"domain_scores_codex":[0.9991102,0.0000216052,0.0001707409,0.000412387,0.0001104889,0.0001746304],"domain_scores_gemma":[0.9995221,0.00001043205,0.00004741645,0.0001811396,0.00005446377,0.00018443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003790391,0.0001338465,0.006056627,0.00006530345,0.000006467936,9.702396e-7,0.0002390966,2.833236e-7,0.9883813,0.00003555514,0.0008609665,0.004181726],"study_design_scores_gemma":[0.002096204,0.00008437841,0.02271684,0.00002921432,0.00001721042,0.000003391523,0.0001720361,0.0001384139,0.9467211,0.0002104138,0.02760466,0.000206184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965605,0.0004965455,0.0001024073,0.002008745,0.0001074169,0.0005750475,0.000103467,0.00000852768,0.00003740683],"genre_scores_gemma":[0.9978248,0.0004687576,0.0004362052,0.0005757719,0.0001728331,0.0002861544,0.00009577208,0.00001522211,0.0001244554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0416602,"threshold_uncertainty_score":0.5222493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703224824975776,"score_gpt":0.2890033922126642,"score_spread":0.2719711439629065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}