{"id":"W2026044536","doi":"10.1016/j.phrs.2011.04.002","title":"Matrix metalloproteinases: Targets for doxycycline to prevent the vascular alterations of hypertension","year":2011,"lang":"en","type":"review","venue":"Pharmacological Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Matrix metalloproteinase; Medicine; Extracellular matrix; Doxycycline; Pathogenesis; Pathophysiology of hypertension; Blood pressure; Vascular smooth muscle; Downregulation and upregulation; Internal medicine; Pharmacology; Bioinformatics; Cardiology; Biology; Cell biology; Antibiotics; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002379329,0.0002723739,0.0006978561,0.0001164234,0.0002289219,0.0000232317,0.0007471939,0.0003216063,0.0001843176],"category_scores_gemma":[0.0009139497,0.0001507756,0.0006675281,0.0002630196,0.0001139922,0.000003617516,0.0006276474,0.0004108357,0.00004862447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003154975,"about_ca_system_score_gemma":0.0002783025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001309923,"about_ca_topic_score_gemma":0.000002030884,"domain_scores_codex":[0.9971769,0.0008468619,0.000518523,0.0005922008,0.0003629526,0.0005024882],"domain_scores_gemma":[0.9985477,0.0001971699,0.0001294948,0.0004718513,0.0004523296,0.0002014268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002606358,0.001441277,6.065757e-8,0.004216812,0.001106476,0.00001505697,0.0000216499,0.000006571452,0.5709338,0.001164193,0.02590738,0.3949261],"study_design_scores_gemma":[0.000174331,0.0009323414,7.038553e-8,0.0003112031,0.0003043631,0.000005500933,0.000004110671,0.00001010392,0.1655449,0.0003221015,0.8322378,0.0001531751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000175499,0.9915904,0.00154258,0.0001144982,0.0001573731,0.006176218,0.0001263914,0.000009238098,0.000107732],"genre_scores_gemma":[0.0009082343,0.9912696,0.001550493,0.0001063512,0.0006115348,0.004546508,0.0002402292,0.00003999439,0.0007270873],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8063304,"threshold_uncertainty_score":0.6148449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2627288459180463,"score_gpt":0.4786014166764971,"score_spread":0.2158725707584508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}