{"id":"W2026046421","doi":"10.1371/journal.pone.0066436","title":"Eukaryotic Translation Elongation Factor 1-Alpha 1 Inhibits p53 and p73 Dependent Apoptosis and Chemotherapy Sensitivity","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Canadian Cancer Society Research Institute; Hospital for Sick Children; Ministerio de Economía y Competitividad","keywords":"Eukaryotic translation elongation factor 1 alpha 1; Gene silencing; Gene knockdown; Apoptosis; Small interfering RNA; Cell biology; Biology; Cancer research; Cell culture; RNA; Transfection; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013287,0.0002951901,0.0003289127,0.0003075677,0.0001389744,0.0001870274,0.0001474994,0.0001727578,0.0009929021],"category_scores_gemma":[0.0001431998,0.0000938322,0.0001912786,0.0001891277,0.0001755853,0.0001188567,0.0001188272,0.0004925555,0.0002351968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002297563,"about_ca_system_score_gemma":0.0001960097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004319787,"about_ca_topic_score_gemma":0.001040429,"domain_scores_codex":[0.9999112,0.00001571497,0.00000906084,0.00001057867,0.00002373208,0.00002975472],"domain_scores_gemma":[0.9999242,0.00001970214,0.00002397345,0.000008425035,0.000006780729,0.00001695353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005782021,0.0002160703,0.0004359819,0.00006644205,0.00001651941,0.000109434,0.00001843633,0.0002416966,0.9853629,0.0001481721,0.0002458273,0.01256043],"study_design_scores_gemma":[0.00006278397,0.0014045,0.005680631,0.000009766583,0.00002769734,0.0003028607,0.0000170438,0.001013113,0.9869623,0.00007725734,0.00443754,0.000004620108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896933,0.006557294,0.001399989,0.0001926496,0.00004867477,0.00003580379,0.0001411214,0.0001164892,0.001814718],"genre_scores_gemma":[0.9949611,0.002168169,0.0006927592,0.00004637476,0.00001443886,0.00002609544,0.000273586,0.00001142476,0.001806007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009929021,"threshold_uncertainty_score":0.003321588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03371327880646099,"score_gpt":0.2214662005945139,"score_spread":0.1877529217880529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}