{"id":"W2026048257","doi":"10.1038/sj.leu.2402196","title":"Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells","year":2001,"lang":"en","type":"article","venue":"Leukemia","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Ontario Institute for Cancer Research; Institute for Biological Sciences; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Medical Research Council; University of Pennsylvania","keywords":"Lovastatin; Geranylgeranylation; Farnesyl pyrophosphate; Geranylgeranyl pyrophosphate; Mevalonic acid; Mevalonate pathway; Farnesyl-diphosphate farnesyltransferase; Biology; Apoptosis; Farnesol; Dolichol; Farnesyltransferase inhibitor; Geranylgeraniol; Myeloid leukemia; HMG-CoA reductase; Hydroxymethylglutaryl-CoA reductase; Biochemistry; Pharmacology; Cancer research; Prenylation; Cholesterol; Farnesyltransferase; Reductase; Enzyme; ATP synthase; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490221,0.0002297898,0.0004373467,0.0001672784,0.0003317831,0.0002743987,0.0002479089,0.0002483987,0.001342894],"category_scores_gemma":[0.0001637866,0.0001732386,0.0002774931,0.0002663273,0.0002507092,0.0002126439,0.0001595458,0.0005133687,0.000440801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004253444,"about_ca_system_score_gemma":0.0002653092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008757969,"about_ca_topic_score_gemma":0.00136589,"domain_scores_codex":[0.9998119,0.00003742321,0.00002225872,0.00002905043,0.00004174053,0.0000575423],"domain_scores_gemma":[0.9998974,0.00002557147,0.00001978005,0.00002728366,0.0000106787,0.00001931095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003771606,0.00003230054,0.0001720004,0.00002536515,0.000007023095,0.00004632207,0.00001389164,0.00004683977,0.9980258,0.0002085884,0.00004982156,0.0009949736],"study_design_scores_gemma":[0.0000412339,0.0002343083,0.002649685,0.000002085665,0.00002326778,0.0002678939,0.00001799346,0.0004797399,0.9925613,0.00007914029,0.003640418,0.000002930832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937217,0.001871165,0.002434287,0.0002547486,0.00003796567,0.00003020718,0.0003641573,0.0001253601,0.001160553],"genre_scores_gemma":[0.9965907,0.0005451242,0.001189027,0.00004372806,0.000006728901,0.00002204055,0.0004490962,0.00001384415,0.001139531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342894,"threshold_uncertainty_score":0.004492402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211211701704567,"score_gpt":0.2491729031369084,"score_spread":0.2370607861198627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}