{"id":"W2026071766","doi":"10.1158/1535-7163.pms-pr12","title":"Abstract PR12: A genome-wide shRNA screen reveals that inhibiting kinases potentiates the anti-breast cancer activity of fluvastatin","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Fluvastatin; Small hairpin RNA; Kinase; Cancer research; RNA interference; Gene knockdown; Pharmacology; Small interfering RNA; Biology; Medicine; Simvastatin; Transfection; Cell culture; Cell biology; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002355246,0.00035999,0.0003880499,0.00006016306,0.0001676554,0.00008165793,0.0004159774,0.000176281,0.0001798387],"category_scores_gemma":[0.00001802442,0.0002808592,0.0002666163,0.0001854886,0.0002371524,0.00002229788,0.0001646016,0.0002265272,0.000005534265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004669135,"about_ca_system_score_gemma":0.0002299572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00281852,"about_ca_topic_score_gemma":0.0002349701,"domain_scores_codex":[0.9981377,0.0001310399,0.0003461509,0.0004892139,0.0003620709,0.0005338482],"domain_scores_gemma":[0.9986056,0.00003520129,0.0003848913,0.0005776542,0.0002865098,0.0001101059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006774064,0.00007738325,0.01141331,0.00006794417,0.0003955757,4.934019e-7,0.0001285229,0.0004924793,0.9623603,0.0000126582,0.0008497682,0.02413381],"study_design_scores_gemma":[0.0007531312,0.00005372479,0.3229917,0.0001060537,0.0002110074,0.00001033093,0.0001794845,0.00006129329,0.653407,0.0001032022,0.02167459,0.0004484796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790457,0.01630521,0.001093036,0.001396981,0.0009426105,0.000643726,0.0003367644,0.00002220613,0.0002136918],"genre_scores_gemma":[0.990363,0.005265343,0.0001540244,0.002084457,0.001643139,0.0001968715,0.00004745021,0.00007643062,0.0001692763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3115784,"threshold_uncertainty_score":0.9999644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189061889641678,"score_gpt":0.2651292238012099,"score_spread":0.2462230348370421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}