{"id":"W2026071977","doi":"10.1016/j.bmcl.2009.08.085","title":"Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Pharmacokinetics; Phenanthrene; Oral administration; Orally active; Analgesic; Hyperalgesia; In vitro; Stereochemistry; Biochemistry; Nociception; Receptor; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001251938,0.0003400147,0.0005550571,0.0000738427,0.0001038513,0.0000224337,0.0001314181,0.0001569717,0.00006279879],"category_scores_gemma":[0.0002719793,0.0002831823,0.0001328196,0.0003632229,0.0003937769,0.0002124437,0.00003905245,0.0002725366,0.000004721368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404467,"about_ca_system_score_gemma":0.0002297243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001335277,"about_ca_topic_score_gemma":0.000004085512,"domain_scores_codex":[0.9981743,0.00002166986,0.0004488619,0.0004912529,0.0004825267,0.000381464],"domain_scores_gemma":[0.9988974,0.00007075111,0.0004100687,0.0002851908,0.0001094212,0.0002272147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005092566,0.0001614033,0.007780117,0.0001327394,0.0001447111,0.00009158273,0.0005830313,8.957969e-7,0.9849756,0.00002529047,0.0009438027,0.004651535],"study_design_scores_gemma":[0.001947386,0.0001408468,0.1349623,0.0004427155,0.0002902818,0.0002745526,0.000493461,0.00001750208,0.8609905,0.00008633064,0.0000972228,0.00025693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887787,0.001382868,0.00009771073,0.008836216,0.0001265991,0.0002451905,0.00001899799,0.00007707821,0.0004367131],"genre_scores_gemma":[0.9976038,0.0002092911,0.00008252815,0.00117511,0.0006691569,0.000004476521,0.0001086009,0.00002765959,0.0001194112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1271822,"threshold_uncertainty_score":0.999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006813593581799883,"score_gpt":0.2365452239560218,"score_spread":0.2297316303742219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}