{"id":"W2026071977","doi":"10.1016/j.bmcl.2009.08.085","title":"Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Pharmacokinetics; Phenanthrene; Oral administration; Orally active; Analgesic; Hyperalgesia; In vitro; Stereochemistry; Biochemistry; Nociception; Receptor; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426672,0.0003093828,0.0002824442,0.0001966237,0.0001133859,0.0002527685,0.0003732446,0.0002516492,0.001220947],"category_scores_gemma":[0.000175848,0.0001527463,0.0001373096,0.0001471095,0.0001409643,0.0002169346,0.000182793,0.0004636434,0.0003066191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002861482,"about_ca_system_score_gemma":0.0001755771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002211489,"about_ca_topic_score_gemma":0.0008706329,"domain_scores_codex":[0.9999337,0.0000122476,0.000004584091,0.000009922337,0.00001590025,0.00002373502],"domain_scores_gemma":[0.9999565,0.000008207843,0.0000108756,0.000004718846,0.000006699634,0.00001305398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006564315,0.000195843,0.0002882766,0.0001463802,0.00002118429,0.0003577619,0.0000580822,0.001070291,0.9729593,0.0008947912,0.0004679242,0.02288353],"study_design_scores_gemma":[0.0004175687,0.003125975,0.002288719,0.00001908978,0.00006191741,0.0008912244,0.00002723825,0.002559124,0.9771236,0.00022681,0.01324078,0.00001779309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97487,0.01040605,0.007992814,0.0003580893,0.0001091661,0.0002107933,0.0005424966,0.0001665615,0.005344111],"genre_scores_gemma":[0.9866009,0.004532691,0.004531974,0.0001051488,0.00003562431,0.00006276841,0.0004716094,0.00001374616,0.003645532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001220947,"threshold_uncertainty_score":0.004084468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006813593581799883,"score_gpt":0.2365452239560218,"score_spread":0.2297316303742219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}