{"id":"W2026072962","doi":"10.1074/jbc.m309917200","title":"DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"","keywords":"DNA damage; Checkpoint Kinase 2; DNA-PKcs; Biology; G2-M DNA damage checkpoint; DNA repair; CHEK1; Cell biology; Molecular biology; DNA; Kinase; Protein kinase A; Cell cycle checkpoint; Apoptosis; Biochemistry; Cell cycle; Protein-Serine-Threonine Kinases","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003438753,0.0001977991,0.0004887729,0.00004787688,0.00003545792,0.00001346182,0.0001061723,0.0003108736,0.0001023391],"category_scores_gemma":[0.000712138,0.000138407,0.0001949932,0.0001149227,0.0001101498,0.00004627457,0.00007567876,0.0005372891,0.00000178168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696435,"about_ca_system_score_gemma":0.0001255596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002190441,"about_ca_topic_score_gemma":0.000001167532,"domain_scores_codex":[0.9984633,0.00003689389,0.0006936746,0.0002327743,0.0003467648,0.0002266063],"domain_scores_gemma":[0.9987618,0.00002885309,0.0005262762,0.000202972,0.0001897441,0.0002903942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001031876,0.0003922306,0.0005185953,0.0001841549,0.00007752921,0.000766762,0.00002162394,0.00009499507,0.9960858,0.00004955034,0.000004792741,0.0007720919],"study_design_scores_gemma":[0.002833744,0.0007938858,0.01877535,0.0006275211,0.00009542137,0.0005878361,0.00002912999,0.00002681676,0.9753537,0.0006624935,0.00006884082,0.0001452237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998101,0.0003247432,0.0003715765,0.0006444003,0.00004601735,0.0002178137,0.00001397749,0.00001867365,0.000261825],"genre_scores_gemma":[0.9984633,0.00008457784,0.0011636,0.00005246198,0.0001547609,0.000005450731,0.00002040927,0.00001508902,0.00004033708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02073206,"threshold_uncertainty_score":0.5644076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866429265847789,"score_gpt":0.2526008019533246,"score_spread":0.2339365092948467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}