{"id":"W2026072962","doi":"10.1074/jbc.m309917200","title":"DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"","keywords":"DNA damage; Checkpoint Kinase 2; DNA-PKcs; Biology; G2-M DNA damage checkpoint; DNA repair; CHEK1; Cell biology; Molecular biology; DNA; Kinase; Protein kinase A; Cell cycle checkpoint; Apoptosis; Biochemistry; Cell cycle; Protein-Serine-Threonine Kinases","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142229,0.0005609163,0.0003135896,0.0002314969,0.0001203129,0.0003240059,0.0002014418,0.0002046626,0.00149503],"category_scores_gemma":[0.0002097793,0.000171267,0.0002710019,0.0001647847,0.0002535499,0.0002850037,0.0004492514,0.0004992754,0.0003990364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002503672,"about_ca_system_score_gemma":0.0002063528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142203,"about_ca_topic_score_gemma":0.0003914918,"domain_scores_codex":[0.9997738,0.00003787687,0.00001434799,0.00004483356,0.00005740888,0.00007169988],"domain_scores_gemma":[0.9998397,0.00003613437,0.00002892399,0.0000252401,0.0000126292,0.00005733639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002120335,0.00003220994,0.0002832622,0.00003139614,0.000004980474,0.00007684221,0.000006855314,0.00004043358,0.9983101,0.00007830184,0.0000267139,0.0008968934],"study_design_scores_gemma":[0.00003925215,0.0005292082,0.005530929,0.000003898323,0.00001365398,0.0003858084,0.00001466877,0.0007122523,0.9914137,0.00008374383,0.001270006,0.000002776092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992792,0.002522908,0.003078168,0.00008586,0.00004033252,0.00003960077,0.0001112056,0.00008105991,0.001248858],"genre_scores_gemma":[0.9944264,0.000848456,0.001984267,0.0000363528,0.00002099301,0.00004648973,0.0002303195,0.00001290781,0.002393855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149503,"threshold_uncertainty_score":0.005001366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866429265847789,"score_gpt":0.2526008019533246,"score_spread":0.2339365092948467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}