{"id":"W2026093192","doi":"10.1007/s00775-012-0930-z","title":"Target binding improves relaxivity in aptamer–gadolinium conjugates","year":2012,"lang":"en","type":"article","venue":"JBIC Journal of Biological Inorganic Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Carleton University","funders":"","keywords":"Chemistry; Gadolinium; Aptamer; Conjugate; Combinatorial chemistry; Biophysics; Molecular biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007704096,0.000211099,0.0003717981,0.00004332285,0.00004935422,0.00001515683,0.0002686046,0.000410611,0.00002988322],"category_scores_gemma":[0.0006135015,0.0001503491,0.0002071256,0.0001874413,0.0001887155,0.00001346413,0.000141338,0.000409319,0.00000539908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005331053,"about_ca_system_score_gemma":0.00005891368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002681929,"about_ca_topic_score_gemma":5.666572e-7,"domain_scores_codex":[0.9985859,0.00007707755,0.0005696297,0.0002328465,0.0001347261,0.0003997952],"domain_scores_gemma":[0.999025,0.00003780154,0.000433421,0.0002245579,0.0001106485,0.0001685921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007988493,0.0001688513,0.04083306,0.00001223107,0.00004711781,0.000007572788,0.00001268881,5.75176e-7,0.9580311,0.000003382591,0.0003044068,0.0004991461],"study_design_scores_gemma":[0.0003139657,0.0001460945,0.00538929,0.00003068241,0.00001914868,0.0002119363,0.0001563785,0.000003129159,0.9892433,0.00009534093,0.004177714,0.0002130136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977413,0.001364275,0.0002532398,0.0001318411,0.0001094431,0.00004799067,0.000008341484,0.00001527329,0.0003282506],"genre_scores_gemma":[0.9957976,0.0008133396,0.002487126,0.0001384176,0.0005724114,0.00000131151,0.00002890691,0.0000137351,0.0001471517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03544376,"threshold_uncertainty_score":0.6131059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150910762756403,"score_gpt":0.2745948746327794,"score_spread":0.259503798357139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}