{"id":"W2026094220","doi":"10.1016/j.ncl.2004.09.005","title":"Natalizumab and other monoclonal antibodies","year":2005,"lang":"en","type":"review","venue":"Neurologic Clinics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Natalizumab; Monoclonal antibody; Medicine; Multiple sclerosis; Cell adhesion molecule; Central nervous system; Immunology; Neural cell adhesion molecule; Cell adhesion; Monoclonal; Antibody; Adhesion; Neuroscience; Cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004275977,0.0005954644,0.002292159,0.0002365223,0.0001405934,0.00004788561,0.0002927049,0.0006890778,0.0004765537],"category_scores_gemma":[0.0003642385,0.0003896507,0.0006987825,0.0002099954,0.0004286376,0.0000391326,0.0003935636,0.001529902,0.0004529179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002833651,"about_ca_system_score_gemma":0.000280446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001640819,"about_ca_topic_score_gemma":0.000006215626,"domain_scores_codex":[0.9969568,0.0002291904,0.0009193294,0.0008253347,0.0004965622,0.0005728342],"domain_scores_gemma":[0.9978227,0.0009550463,0.0003013751,0.0005415873,0.00007373867,0.0003055498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000130561,0.0001323707,0.0005631582,0.005582483,0.0001588381,0.0004181988,0.00001203456,1.16765e-7,1.398737e-7,0.0003931638,0.002067546,0.9905414],"study_design_scores_gemma":[0.0003968813,0.0007291185,0.0002187088,0.001029955,0.0006205391,0.001805134,0.000002518161,0.00004126329,1.236054e-7,0.00009867185,0.9947422,0.0003148485],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006691852,0.9902896,0.000001065132,0.0005869986,0.0002897675,0.000748603,0.0002250911,0.00009784842,0.007091873],"genre_scores_gemma":[0.00001955782,0.9890668,0.0004346805,0.00304174,0.001149147,0.00004091746,0.0001088089,0.00008069215,0.006057627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9926747,"threshold_uncertainty_score":0.9998555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.188158190407748,"score_gpt":0.4672519951408323,"score_spread":0.2790938047330843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}