{"id":"W2026122112","doi":"10.4161/mabs.1.2.7945","title":"High level expression of functional human IgMs in human PER.C6® cells","year":2009,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Recombinant DNA; Cell culture; Antibody; Biology; Monoclonal antibody; Cytotoxicity; Random hexamer; Chinese hamster ovary cell; Immunoglobulin M; Molecular biology; Immunoglobulin G; Biochemistry; Gene; Immunology; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007045701,0.0006466142,0.0004541577,0.000342159,0.0002073448,0.0007179716,0.0005785594,0.0004776107,0.001372175],"category_scores_gemma":[0.0002700208,0.0002262723,0.0004372073,0.0005785784,0.0001990561,0.0002160122,0.0003484778,0.001046757,0.001442354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003529971,"about_ca_system_score_gemma":0.0001742731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000519811,"about_ca_topic_score_gemma":0.0004335346,"domain_scores_codex":[0.9995072,0.00008919471,0.00007320587,0.00009105146,0.0001774696,0.00006201595],"domain_scores_gemma":[0.9997428,0.00004681076,0.00005460804,0.0000762621,0.0000448536,0.0000347739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005332792,0.00003257903,0.00005236264,0.00004398335,0.000004515907,0.00002773185,0.00002025546,0.0001056685,0.9981713,0.0001239395,0.0001094136,0.001254912],"study_design_scores_gemma":[0.00001939674,0.0002958181,0.0008562887,0.00000875982,0.00002537011,0.0002097909,0.00001546838,0.001506555,0.9893277,0.00003915656,0.007689083,0.000006768303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9051994,0.002943241,0.07228561,0.0003360642,0.000257017,0.0005799181,0.009270823,0.001112026,0.008015843],"genre_scores_gemma":[0.8793488,0.002692154,0.07613193,0.0001656306,0.00009450178,0.000379083,0.02223358,0.0002941215,0.01866012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372175,"threshold_uncertainty_score":0.004590452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06835872217654829,"score_gpt":0.3375265000282766,"score_spread":0.2691677778517283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}