{"id":"W2026122112","doi":"10.4161/mabs.1.2.7945","title":"High level expression of functional human IgMs in human PER.C6® cells","year":2009,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Recombinant DNA; Cell culture; Antibody; Biology; Monoclonal antibody; Cytotoxicity; Random hexamer; Chinese hamster ovary cell; Immunoglobulin M; Molecular biology; Immunoglobulin G; Biochemistry; Gene; Immunology; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001484243,0.0001105264,0.0002396842,0.0001542121,0.00009107429,0.00000709679,0.00008660667,0.00007700543,0.001991322],"category_scores_gemma":[0.00001067776,0.00008533258,0.00008207934,0.0001074076,0.00006930466,0.00004318334,0.00004183198,0.0002314247,0.00006466494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003577697,"about_ca_system_score_gemma":0.00003158714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003567972,"about_ca_topic_score_gemma":0.00002900894,"domain_scores_codex":[0.9988508,0.00003263318,0.0002659729,0.0001957053,0.0004277769,0.0002271766],"domain_scores_gemma":[0.9995769,0.00003004962,0.00004602209,0.0001751177,0.00007463331,0.00009726026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002127941,0.0003104935,0.005721979,0.00006085348,0.000006952908,0.00003704922,0.000104423,0.00001714791,0.982307,0.003435284,0.006465822,0.001320159],"study_design_scores_gemma":[0.001358272,0.0005506102,0.642224,0.0001684776,0.000008583658,0.00001175427,0.00004988505,0.0000175543,0.3485403,0.001791517,0.005168144,0.000110844],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919704,0.0001192338,0.00003398028,0.001267729,0.00006951287,0.0001464307,0.00001853147,0.00001648612,0.006357683],"genre_scores_gemma":[0.9807052,0.00001530821,0.0003146206,0.0002503965,0.0002281128,0.000004839854,0.00008678148,0.000008451279,0.01838631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.636502,"threshold_uncertainty_score":0.998921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06835872217654829,"score_gpt":0.3375265000282766,"score_spread":0.2691677778517283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}