{"id":"W2026122131","doi":"10.1074/jbc.m110.126433","title":"Tumor Necrosis Factor Receptor-associated Factor-6 and Ribosomal S6 Kinase Intracellular Pathways Link the Angiotensin II AT1 Receptor to the Phosphorylation and Activation of the IκB Kinase Complex in Vascular Smooth Muscle Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Ribosomal s6 kinase; IκB kinase; Phosphorylation; Cell biology; Angiotensin II; MAP kinase kinase kinase; Kinase; Signal transduction; Cancer research; Biology; Chemistry; Protein kinase A; NF-κB; Receptor; Biochemistry; Protein kinase B; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798017,0.0004168134,0.0001967836,0.0002827715,0.0001766435,0.000345285,0.000227603,0.0002526093,0.001628777],"category_scores_gemma":[0.0001111069,0.0001727092,0.0003516269,0.0001531557,0.0002469064,0.0003567357,0.000350928,0.0006622842,0.0008679922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229963,"about_ca_system_score_gemma":0.0002497911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002290752,"about_ca_topic_score_gemma":0.0002856745,"domain_scores_codex":[0.9998419,0.00002434816,0.00001071217,0.00003656929,0.0000468321,0.00003958123],"domain_scores_gemma":[0.9999053,0.000003919942,0.00004079317,0.000008553535,0.00001351394,0.0000279444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003221973,0.00007213403,0.0003931658,0.0002008368,0.00001548354,0.0001886261,0.00002972548,0.0001502674,0.9907334,0.0008813978,0.0002056837,0.006807087],"study_design_scores_gemma":[0.000158735,0.00101096,0.03151283,0.00006568078,0.00008744404,0.002030439,0.0001137156,0.003302295,0.9301114,0.002186991,0.02939228,0.00002720162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9021736,0.05709371,0.02399492,0.001164641,0.0006288046,0.0001126387,0.0007019768,0.0004938972,0.01363568],"genre_scores_gemma":[0.9688749,0.01704269,0.005327411,0.0001650444,0.0001495598,0.00006558072,0.0006851157,0.00002107644,0.007668652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628777,"threshold_uncertainty_score":0.005448818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907018569659446,"score_gpt":0.2169293791133,"score_spread":0.1978591934167055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}