{"id":"W2026122131","doi":"10.1074/jbc.m110.126433","title":"Tumor Necrosis Factor Receptor-associated Factor-6 and Ribosomal S6 Kinase Intracellular Pathways Link the Angiotensin II AT1 Receptor to the Phosphorylation and Activation of the IκB Kinase Complex in Vascular Smooth Muscle Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Ribosomal s6 kinase; IκB kinase; Phosphorylation; Cell biology; Angiotensin II; MAP kinase kinase kinase; Kinase; Signal transduction; Cancer research; Biology; Chemistry; Protein kinase A; NF-κB; Receptor; Biochemistry; Protein kinase B; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000584393,0.0002327973,0.0002952903,0.00002162617,0.0002112242,0.0000419862,0.0003741872,0.0003574978,0.00006213476],"category_scores_gemma":[0.0008740146,0.000122751,0.0001857359,0.0001777448,0.0002679498,0.00001278208,0.0002453576,0.0005952971,6.973955e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003971576,"about_ca_system_score_gemma":0.00007496679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002294684,"about_ca_topic_score_gemma":0.000008054339,"domain_scores_codex":[0.9985418,0.0001687626,0.0005016151,0.0002940251,0.0002416921,0.0002521457],"domain_scores_gemma":[0.9986552,0.000124224,0.0005384794,0.0003307855,0.0002301725,0.0001211106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041346,0.0001061051,0.00281697,0.00001138239,0.00003618051,0.000001529787,0.0001711952,0.00002600209,0.9942549,0.00000344171,0.0002156238,0.002252527],"study_design_scores_gemma":[0.0005266062,0.0002359189,0.07638106,0.00004614071,0.0000160632,0.000003025143,0.0001000552,0.00005227233,0.9150823,0.00003307116,0.00736709,0.0001563596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978909,0.0003147123,0.00004944211,0.00122673,0.0001493151,0.0002453191,0.0001084887,0.000006146451,0.000008968554],"genre_scores_gemma":[0.998929,0.000118106,0.0003551835,0.0002522812,0.0002763763,0.000005471239,0.00003571555,0.00001644784,0.00001137299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07917257,"threshold_uncertainty_score":0.500564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907018569659446,"score_gpt":0.2169293791133,"score_spread":0.1978591934167055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}