{"id":"W2026136231","doi":"10.1523/jneurosci.4810-06.2007","title":"A <i>Drosophila</i> Model of Mutant Human Parkin-Induced Toxicity Demonstrates Selective Loss of Dopaminergic Neurons and Dependence on Cellular Dopamine","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging","keywords":"Parkin; Dopaminergic; Dopamine transporter; Dopamine; Mutant; Gene knockdown; Biology; Phenotype; Drosophila melanogaster; Monoamine neurotransmitter; Cell biology; Parkinson's disease; Neuroscience; Genetics; Disease; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004202267,0.000195736,0.0004539869,0.000251904,0.0001005907,0.00001284608,0.0001909554,0.00005484355,0.000001569411],"category_scores_gemma":[0.0001744772,0.0001495255,0.0001258313,0.0003940378,0.0002297837,0.000164518,0.00004708231,0.0002587518,2.622703e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004451362,"about_ca_system_score_gemma":0.0001694926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008410072,"about_ca_topic_score_gemma":0.000003400188,"domain_scores_codex":[0.9980909,0.0000435939,0.0005822044,0.000297314,0.0006975159,0.0002884837],"domain_scores_gemma":[0.998515,0.00009191733,0.0006432837,0.0002012769,0.0002348979,0.0003136025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003432009,0.0008347242,0.006336479,0.00003418851,0.00001672694,0.0008962928,0.00006201991,0.0002410705,0.9907721,0.0002165983,0.000001563085,0.000245057],"study_design_scores_gemma":[0.001459573,0.003587631,0.07473961,0.0001359506,0.0001631364,0.0006875612,0.00002174794,0.003560266,0.9150786,0.0004545789,0.000006139114,0.0001052349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984955,0.0001063542,0.0007859432,0.0001083853,0.0001079452,0.0001708695,0.00001726748,0.000007069052,0.0002006228],"genre_scores_gemma":[0.9993307,0.0000671157,0.000340239,0.0001912915,0.00003611836,0.000001050512,3.734816e-7,0.00001366329,0.00001942805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07569351,"threshold_uncertainty_score":0.6097474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331205483970295,"score_gpt":0.2842524697782615,"score_spread":0.2509404149385585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}