{"id":"W2026136448","doi":"10.1016/j.abb.2006.11.030","title":"Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies","year":2006,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Homology modeling; CYP24A1; Cytochrome P450; Stereochemistry; Active site; Biochemistry; Mutant; Docking (animal); Enzyme; Mutagenesis; Chemistry; Binding site; Substrate (aquarium); Biology; Gene; Calcitriol receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002468899,0.0006085314,0.0008204959,0.0005091876,0.0006129789,0.0006261906,0.000854842,0.0009562784,0.002383812],"category_scores_gemma":[0.0009378635,0.0004133056,0.0005751578,0.0005338467,0.0002930857,0.0004063896,0.0002715251,0.0007550216,0.0006061191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006977591,"about_ca_system_score_gemma":0.0009958247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00369273,"about_ca_topic_score_gemma":0.003603822,"domain_scores_codex":[0.9998925,0.00003078803,0.000006176932,0.00001927324,0.00003532913,0.00001599756],"domain_scores_gemma":[0.9998316,0.00007675732,0.00002199979,0.00001733709,0.00003305986,0.00001928039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001219583,0.0007505962,0.004648868,0.0006189847,0.0001207716,0.003229187,0.0003580172,0.6996691,0.2150748,0.03330219,0.003224662,0.03778319],"study_design_scores_gemma":[0.0002877531,0.000443353,0.001305205,0.00003737996,0.00009019984,0.0005626136,0.0002685555,0.9337666,0.04853542,0.007181496,0.007478279,0.00004307515],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.822405,0.0009621312,0.1648845,0.0008432515,0.00008161674,0.0002822351,0.003121635,0.001162294,0.006257398],"genre_scores_gemma":[0.909166,0.0006835731,0.08271698,0.00006480559,0.00001215425,0.0001757762,0.005670835,0.0001577527,0.001352186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00369273,"threshold_uncertainty_score":0.007974625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05801444745219191,"score_gpt":0.3115788642889309,"score_spread":0.253564416836739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}