{"id":"W2026185344","doi":"10.1083/jcb.200705051","title":"Retinoblastoma tumor suppressor protein–dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit","year":2007,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Biology; Retinoblastoma protein; Cell cycle; Cell biology; Chromatin; Histone H3; Mitosis; Histone; E2F; EZH2; Cell Cycle Protein; Histone methyltransferase; Molecular biology; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008730622,0.0002021875,0.0002003414,0.0002108863,0.0001763749,0.0002610962,0.0001728276,0.0001447203,0.001453383],"category_scores_gemma":[0.0001122214,0.0001478252,0.0002141475,0.0001210282,0.0002885883,0.0001099734,0.0002543302,0.0003918176,0.0006389167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004297874,"about_ca_system_score_gemma":0.0002747002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009768608,"about_ca_topic_score_gemma":0.001988454,"domain_scores_codex":[0.9998915,0.000009383203,0.000006586462,0.00003053908,0.00002580397,0.00003630052],"domain_scores_gemma":[0.9998869,0.00001067677,0.00004174378,0.00001746807,0.00001033971,0.00003287401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001421505,0.00001391277,0.0007569231,0.00002359954,0.000006745217,0.0001012607,0.000008271327,0.0000477384,0.9974107,0.0001841792,0.00007452676,0.001229927],"study_design_scores_gemma":[0.0000241671,0.0001185637,0.02740031,0.000004482922,0.00001449138,0.0007613049,0.0000224508,0.0005427719,0.9688115,0.0001559602,0.002140201,0.000003862534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944875,0.001416974,0.001901804,0.00008132715,0.00001456548,0.000009598525,0.0002675165,0.0001000658,0.001720786],"genre_scores_gemma":[0.9944909,0.0005407911,0.0006942416,0.00003231762,0.000005857993,0.00001012549,0.0005912629,0.00002424803,0.003610406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453383,"threshold_uncertainty_score":0.00486201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009743222745506082,"score_gpt":0.2635561241335249,"score_spread":0.2538129013880188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}