{"id":"W2026185344","doi":"10.1083/jcb.200705051","title":"Retinoblastoma tumor suppressor protein–dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit","year":2007,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Biology; Retinoblastoma protein; Cell cycle; Cell biology; Chromatin; Histone H3; Mitosis; Histone; E2F; EZH2; Cell Cycle Protein; Histone methyltransferase; Molecular biology; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001585548,0.0001729364,0.0005183688,0.0003188241,0.00005335096,0.000003513246,0.0001992556,0.0001686231,0.0002649644],"category_scores_gemma":[0.0001518504,0.0001109307,0.000140962,0.0003963789,0.0001852497,0.00004987143,0.00004498506,0.0005241216,0.00001400361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331827,"about_ca_system_score_gemma":0.0002009117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000691956,"about_ca_topic_score_gemma":0.00002973152,"domain_scores_codex":[0.9983175,0.000234748,0.0006494056,0.000144996,0.000345453,0.0003078305],"domain_scores_gemma":[0.9976217,0.0001763753,0.001251654,0.000283564,0.0005474261,0.0001193376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002614188,0.000275193,0.0001338426,0.00004277728,0.0001530563,0.00009615569,0.0004350149,0.0001122285,0.9954259,0.000006285309,0.0005470392,0.0001582643],"study_design_scores_gemma":[0.003680999,0.003008913,0.0009419761,0.0001491846,0.0004691793,0.0002324352,0.0001607438,0.00007332338,0.9899299,0.0001126881,0.001127854,0.0001127968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991425,0.00122546,0.002066202,0.0004476439,0.0001980486,0.0004012543,0.00001368014,0.00001355615,0.00420909],"genre_scores_gemma":[0.9977866,0.00007807428,0.0007678368,0.0001676618,0.00009292446,0.000001229932,0.000009909624,0.00002802017,0.001067783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006361495,"threshold_uncertainty_score":0.4523624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009743222745506082,"score_gpt":0.2635561241335249,"score_spread":0.2538129013880188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}