{"id":"W2026225517","doi":"10.1038/nrneurol.2011.190","title":"MRI monitoring of immunomodulation in relapse-onset multiple sclerosis trials","year":2011,"lang":"en","type":"review","venue":"Nature Reviews Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of British Columbia","funders":"National Multiple Sclerosis Society","keywords":"Medicine; Multiple sclerosis; Clinical trial; Surrogate endpoint; Placebo; Intensive care medicine; Medical physics; Physical medicine and rehabilitation; Physical therapy; Pathology; Alternative medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00573363,0.0007960388,0.01034263,0.001075704,0.00006696351,0.00001156825,0.0005322866,0.002069923,0.00009406247],"category_scores_gemma":[0.02155955,0.0005497059,0.001836684,0.001119867,0.000198887,0.00009284434,0.0003252467,0.004418307,0.0001020456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013792,"about_ca_system_score_gemma":0.0002549837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005547741,"about_ca_topic_score_gemma":0.00002211224,"domain_scores_codex":[0.9894468,0.004736191,0.003708884,0.0009962046,0.0004353768,0.0006765696],"domain_scores_gemma":[0.9927701,0.003305936,0.00216542,0.001359544,0.0002333447,0.0001656397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002381788,0.0001862828,0.003465378,0.0266973,0.0002494808,0.00002000079,0.00005682779,3.335618e-7,0.00004097421,0.0000090794,0.001126483,0.9679097],"study_design_scores_gemma":[0.001210582,0.0003924258,0.01383257,0.02953644,0.0008450975,0.00006326099,0.000002018254,0.000003657491,0.0000135053,0.000006956814,0.9538117,0.0002817863],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001979261,0.9919303,0.000006625665,0.0001214236,0.0011318,0.006297325,0.00007212738,0.00004310817,0.0001993396],"genre_scores_gemma":[0.000642903,0.9966906,0.0008672132,0.00008080235,0.0005172742,0.0009090736,0.0001234406,0.0001102504,0.00005843381],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9676279,"threshold_uncertainty_score":0.9996954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3191147036382875,"score_gpt":0.439075443729121,"score_spread":0.1199607400908335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}