{"id":"W2026230149","doi":"10.1016/j.bpc.2004.07.031","title":"Modes and consequences of thrombin's interaction with fibrin","year":2004,"lang":"en","type":"review","venue":"Biophysical Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Heart and Stroke Foundation of Canada","keywords":"Thrombin; Fibrin; Chemistry; Thrombomodulin; Discovery and development of direct thrombin inhibitors; Thrombus; Thromboplastin; Coagulation; Biophysics; Pharmacology; Biochemistry; Immunology; Internal medicine; Platelet; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002334603,0.0002194831,0.0009917086,0.00001577921,0.0000191191,0.0000108644,0.0000507169,0.0001839269,0.00005482654],"category_scores_gemma":[0.00001190068,0.0001507694,0.0001499193,0.0001120964,0.0002200537,0.00003309489,0.00002804439,0.0002049442,0.000005968649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004301854,"about_ca_system_score_gemma":0.000220745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001038343,"about_ca_topic_score_gemma":9.158121e-8,"domain_scores_codex":[0.9992301,0.00001122399,0.0002349585,0.0002623433,0.0001605485,0.0001008002],"domain_scores_gemma":[0.9994348,0.00003598405,0.0002007143,0.0001968088,0.0000440409,0.00008769493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001197233,0.001007011,0.000004898225,0.2347111,0.001307407,0.00006418068,0.00006687951,0.000002380736,0.5169788,0.004476696,0.00004641891,0.2412146],"study_design_scores_gemma":[0.001983939,0.0007332712,0.00001516888,0.131621,0.004551806,0.001235617,0.0002139588,0.00002966757,0.8036389,0.0009074178,0.05410414,0.0009651166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01015467,0.9866559,0.0000299139,0.00005121296,0.00002897523,0.0003938669,0.0000307619,0.00006564803,0.002589041],"genre_scores_gemma":[0.1292647,0.8699443,0.0003817885,0.000009740633,0.0001055655,0.00002128878,0.00008834747,0.00002762726,0.0001567076],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2866601,"threshold_uncertainty_score":0.6148197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04890009668586266,"score_gpt":0.329824145779028,"score_spread":0.2809240490931654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}