{"id":"W2026249004","doi":"10.1002/cbic.200600195","title":"Catalysis and Rational Engineering of trans‐Acting pH6DZ1, an RNA‐Cleaving and Fluorescence‐Signaling Deoxyribozyme with a Four‐Way Junction Structure","year":2006,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Fluorescence; Chemistry; Fluorophore; DNA; Rational design; Moiety; Catalysis; RNA; G-quadruplex; Biosensor; Substrate (aquarium); Biophysics; Photochemistry; Stereochemistry; Combinatorial chemistry; Biochemistry; Nanotechnology; Biology; Gene; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009318127,0.000169904,0.0001748446,0.00005914069,0.00008290236,0.00002881909,0.00005517392,0.0001296003,0.000001057413],"category_scores_gemma":[0.00002238508,0.0001476011,0.00004184278,0.0001258106,0.00008470615,0.00001488206,0.00002444794,0.00008574601,2.223954e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001113207,"about_ca_system_score_gemma":0.00001694023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003794032,"about_ca_topic_score_gemma":0.00003855504,"domain_scores_codex":[0.9991875,0.00001247533,0.0001852818,0.0003420639,0.0001178073,0.0001548542],"domain_scores_gemma":[0.9995812,0.00001022132,0.0001049124,0.0001606854,0.00009228629,0.00005069384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004110999,0.00001727174,0.001110066,0.00003721712,0.00004358616,0.000001539375,0.00002993769,0.0001022843,0.9955987,0.00001330405,0.000007614418,0.002997352],"study_design_scores_gemma":[0.0002484608,0.0001016913,0.00122974,0.00004265113,0.0000761228,0.00003999013,0.00008376691,0.0009611734,0.9969233,0.00003081124,0.00006871661,0.0001935422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917687,0.0002418518,0.007813556,0.00002973003,0.0000105444,0.00006743395,0.000009285889,0.00002816853,0.00003070557],"genre_scores_gemma":[0.978048,0.00002434964,0.02154056,0.00001309091,0.0001366399,0.000002626363,0.0001898345,0.00001887387,0.00002597354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01372701,"threshold_uncertainty_score":0.6018999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00463666297476205,"score_gpt":0.202165675472413,"score_spread":0.197529012497651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}