{"id":"W2026272867","doi":"10.1074/jbc.m301391200","title":"Activation of the Prolyl Hydroxylase Oxygen-sensor Results in Induction of GLUT1, Heme Oxygenase-1, and Nitric-oxide Synthase Proteins and Confers Protection from Metabolic Inhibition to Cardiomyocytes","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Heme oxygenase; Oxygenase; Hydroxylation; Heme; Hypoxia-inducible factors; GLUT1; Biochemistry; Nitric oxide synthase; Biology; Glycolysis; Hypoxia (environmental); Oxidative phosphorylation; Enzyme; Cell biology; Chemistry; Glucose uptake; Oxygen; Endocrinology; Gene; Insulin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521551,0.0003035343,0.0002512395,0.0001084935,0.0001002712,0.0001825879,0.0001624527,0.0001552748,0.00116552],"category_scores_gemma":[0.00009390892,0.0001327986,0.0002197255,0.00007665565,0.0001400358,0.0001261014,0.0001650595,0.0004639848,0.0002506218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138912,"about_ca_system_score_gemma":0.000219038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004639326,"about_ca_topic_score_gemma":0.0009813622,"domain_scores_codex":[0.9998797,0.00002249337,0.00001307619,0.00002858543,0.0000287402,0.00002732835],"domain_scores_gemma":[0.9998797,0.00001914888,0.00003611267,0.00001364951,0.000009298785,0.00004199735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008343824,0.000009026028,0.00007599798,0.00001071754,0.000002378115,0.00001201177,0.00000272495,0.00001019081,0.9994703,0.0000145995,0.000007515023,0.0003010957],"study_design_scores_gemma":[0.00001096843,0.0003230423,0.003614361,0.000001828949,0.000007174741,0.00008194917,0.000008596799,0.0002172575,0.9949186,0.00001007941,0.00080418,0.000002005576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994199,0.001971181,0.002409747,0.00009447726,0.00004088355,0.00002626914,0.0003333808,0.00004672661,0.0008783641],"genre_scores_gemma":[0.9928328,0.001195427,0.002410323,0.00007121458,0.00001623172,0.00003091676,0.0007153257,0.00001376524,0.002714046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00116552,"threshold_uncertainty_score":0.003899038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188993383537858,"score_gpt":0.229190374558251,"score_spread":0.2102910362044652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}